The ACE2 Receptor for COVID-19 Entry Is Expressed on the Surface of Hematopoietic Stem/Progenitor Cells and Endothelial Progenitors As Well As Their Precursor Cells and Becomes Activated in Nlrp3 Inflammasome-Dependent Manner By Virus Spike Protein - a Potential Pathway Leading to a “Cytokine Storm”

Background. The SARS-CoV-2 pandemic, with its high mortality, has become an urgent clinical problem. It is well established that SARS-CoV-2 enters human cells after binding to the angiotensin-converting enzyme 2 (ACE2) receptor and utilizes a spike protein (S) for attachment and entry into the cells...

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Autores principales: Kucia, Magdalena, Bujko, Kamila, Ciechanowicz, Andrzej, Cymer, Monika, Sielatycka, Katarzyna, Ratajczak, Janina, Ratajczak, Mariusz Z
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2020
Materias:
203.Lymphocytes, Lymphocyte Activation, and Immunodeficiency, including HIV and Other Infections
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8330306/
http://dx.doi.org/10.1182/blood-2020-137083

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