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Frequency of Venous Thromboembolism in 6513 Patients with COVID-19: A Retrospective Study
Background: Patients infected with coronavirus 2 (SARS-CoV-2) appear to be at increased risk for venous thromboembolism (VTE), especially if they become critically ill with coronavirus disease 2019 (COVID-19). Some centers have reported very high rates of thrombosis despite anticoagulant prophylaxis...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society of Hematology
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8330347/ http://dx.doi.org/10.1182/blood-2020-141850 |
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author | Crowther, Mark Garcia, David A. Hill, Jason Savage, Bryan Peress, Shira Chang, Kevin Deitelzweig, Steven |
author_facet | Crowther, Mark Garcia, David A. Hill, Jason Savage, Bryan Peress, Shira Chang, Kevin Deitelzweig, Steven |
author_sort | Crowther, Mark |
collection | PubMed |
description | Background: Patients infected with coronavirus 2 (SARS-CoV-2) appear to be at increased risk for venous thromboembolism (VTE), especially if they become critically ill with coronavirus disease 2019 (COVID-19). Some centers have reported very high rates of thrombosis despite anticoagulant prophylaxis. Methods: The electronic health record (EHR) of a New Orleans-based health system was searched for all patients with PCR-confirmed SARS-CoV-2 infection who were either admitted to hospital or treated and discharged from an emergency department between March 1 and May 1, 2020. From this cohort, patients with confirmed VTE (either during or after their hospital encounter) were identified by administrative query of the EHR. Results: Between March 1, 2020 and May 1, 2020, 6,153 patients with COVID-19 were identified; 2,748 of these patients were admitted, while 3,405 received care exclusively through the emergency department. Data on patient outcomes were determined up until and including May 21, 2020. In total, 637 patients required mechanical ventilation and 206 required renal replacement therapy. Within the hospitalized cohort, the overall mortality rate was 24.5% and VTE occurred in 86 patients (3.1%). In the 637 patients who required mechanical ventilation at some point during their hospital stay, 45 developed VTE (7.2%). After a median follow-up of 14.6 days, VTE had been diagnosed in 3 of the 2,075 admitted who were discharged alive (0.14%). Conclusions: Among 6,153 patients with COVID-19 who were hospitalized or treated in emergency departments, we did not find evidence of unusually high VTE risk. Pending further evidence from prospective, controlled trials, our findings support a traditional approach to primary VTE prevention in patients with COVID-19. [Figure: see text] DISCLOSURES: Crowther:Precision Biologicals: Membership on an entity's Board of Directors or advisory committees; Hemostais Reference Laboratories: Honoraria; Pfizer: Speakers Bureau; CSL Behring: Speakers Bureau; Alnylam: Divested equity in a private or publicly-traded company in the past 24 months; Servier Canada: Membership on an entity's Board of Directors or advisory committees; Diagnostica Stago: Speakers Bureau; Asahi Kasei: Membership on an entity's Board of Directors or advisory committees. |
format | Online Article Text |
id | pubmed-8330347 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | American Society of Hematology |
record_format | MEDLINE/PubMed |
spelling | pubmed-83303472021-08-03 Frequency of Venous Thromboembolism in 6513 Patients with COVID-19: A Retrospective Study Crowther, Mark Garcia, David A. Hill, Jason Savage, Bryan Peress, Shira Chang, Kevin Deitelzweig, Steven Blood 322.Disorders of Coagulation or Fibrinolysis Background: Patients infected with coronavirus 2 (SARS-CoV-2) appear to be at increased risk for venous thromboembolism (VTE), especially if they become critically ill with coronavirus disease 2019 (COVID-19). Some centers have reported very high rates of thrombosis despite anticoagulant prophylaxis. Methods: The electronic health record (EHR) of a New Orleans-based health system was searched for all patients with PCR-confirmed SARS-CoV-2 infection who were either admitted to hospital or treated and discharged from an emergency department between March 1 and May 1, 2020. From this cohort, patients with confirmed VTE (either during or after their hospital encounter) were identified by administrative query of the EHR. Results: Between March 1, 2020 and May 1, 2020, 6,153 patients with COVID-19 were identified; 2,748 of these patients were admitted, while 3,405 received care exclusively through the emergency department. Data on patient outcomes were determined up until and including May 21, 2020. In total, 637 patients required mechanical ventilation and 206 required renal replacement therapy. Within the hospitalized cohort, the overall mortality rate was 24.5% and VTE occurred in 86 patients (3.1%). In the 637 patients who required mechanical ventilation at some point during their hospital stay, 45 developed VTE (7.2%). After a median follow-up of 14.6 days, VTE had been diagnosed in 3 of the 2,075 admitted who were discharged alive (0.14%). Conclusions: Among 6,153 patients with COVID-19 who were hospitalized or treated in emergency departments, we did not find evidence of unusually high VTE risk. Pending further evidence from prospective, controlled trials, our findings support a traditional approach to primary VTE prevention in patients with COVID-19. [Figure: see text] DISCLOSURES: Crowther:Precision Biologicals: Membership on an entity's Board of Directors or advisory committees; Hemostais Reference Laboratories: Honoraria; Pfizer: Speakers Bureau; CSL Behring: Speakers Bureau; Alnylam: Divested equity in a private or publicly-traded company in the past 24 months; Servier Canada: Membership on an entity's Board of Directors or advisory committees; Diagnostica Stago: Speakers Bureau; Asahi Kasei: Membership on an entity's Board of Directors or advisory committees. American Society of Hematology 2020-11-05 2021-08-03 /pmc/articles/PMC8330347/ http://dx.doi.org/10.1182/blood-2020-141850 Text en Copyright © 2020 American Society of Hematology. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | 322.Disorders of Coagulation or Fibrinolysis Crowther, Mark Garcia, David A. Hill, Jason Savage, Bryan Peress, Shira Chang, Kevin Deitelzweig, Steven Frequency of Venous Thromboembolism in 6513 Patients with COVID-19: A Retrospective Study |
title | Frequency of Venous Thromboembolism in 6513 Patients with COVID-19: A Retrospective Study |
title_full | Frequency of Venous Thromboembolism in 6513 Patients with COVID-19: A Retrospective Study |
title_fullStr | Frequency of Venous Thromboembolism in 6513 Patients with COVID-19: A Retrospective Study |
title_full_unstemmed | Frequency of Venous Thromboembolism in 6513 Patients with COVID-19: A Retrospective Study |
title_short | Frequency of Venous Thromboembolism in 6513 Patients with COVID-19: A Retrospective Study |
title_sort | frequency of venous thromboembolism in 6513 patients with covid-19: a retrospective study |
topic | 322.Disorders of Coagulation or Fibrinolysis |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8330347/ http://dx.doi.org/10.1182/blood-2020-141850 |
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