Design and synthesis of novel quinazolinones conjugated ibuprofen, indole acetamide, or thioacetohydrazide as selective COX-2 inhibitors: anti-inflammatory, analgesic and anticancer activities

Novel quinazolinones conjugated with indole acetamide (4a–c), ibuprofen (7a–e), or thioacetohydrazide (13a,b, and 14a-d) were designed to increase COX-2 selectivity. The three synthesised series exhibited superior COX-2 selectivity compared with the previously reported quinazolinones and their NSAID...

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Detalles Bibliográficos
Autores principales: Sakr, Asmaa, Rezq, Samar, Ibrahim, Samy M., Soliman, Eman, Baraka, Mohamed M., Romero, Damian G., Kothayer, Hend
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8330735/
https://www.ncbi.nlm.nih.gov/pubmed/34338135
http://dx.doi.org/10.1080/14756366.2021.1956912

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