Cargando…

Discovery of new 3-methylquinoxalines as potential anti-cancer agents and apoptosis inducers targeting VEGFR-2: design, synthesis, and in silico studies

There is an urgent need to design new anticancer agents that can prevent cancer cell proliferation even with minimal side effects. Accordingly, two new series of 3-methylquinoxalin-2(1H)-one and 3-methylquinoxaline-2-thiol derivatives were designed to act as VEGFR-2 inhibitors. The designed derivati...

Descripción completa

Detalles Bibliográficos
Autores principales:	Alanazi, Mohammed M., Alaa, Elwan, Alsaif, Nawaf A., Obaidullah, Ahmad J., Alkahtani, Hamad M., Al-Mehizia, Abdulrahman A., Alsubaie, Sultan M., Taghour, Mohammed S., Eissa, Ibrahim H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8330740/ https://www.ncbi.nlm.nih.gov/pubmed/34325596 http://dx.doi.org/10.1080/14756366.2021.1945591

Ejemplares similares

Discovery of new VEGFR-2 inhibitors based on bis([1, 2, 4]triazolo)[4,3-a:3',4'-c]quinoxaline derivatives as anticancer agents and apoptosis inducers
por: Alsaif, Nawaf A., et al.
Publicado: (2021)

Design, synthesis, docking, ADMET studies, and anticancer evaluation of new 3-methylquinoxaline derivatives as VEGFR-2 inhibitors and apoptosis inducers
por: Alanazi, Mohammed M., et al.
Publicado: (2021)

New quinoxaline-based VEGFR-2 inhibitors: design, synthesis, and antiproliferative evaluation with in silico docking, ADMET, toxicity, and DFT studies
por: Alanazi, Mohammed M., et al.
Publicado: (2021)

A New CDK2 Inhibitor with 3-Hydrazonoindolin-2-One Scaffold Endowed with Anti-Breast Cancer Activity: Design, Synthesis, Biological Evaluation, and In Silico Insights
por: Al-Sanea, Mohammad M., et al.
Publicado: (2021)

Benzoxazole derivatives as new VEGFR-2 inhibitors and apoptosis inducers: design, synthesis, in silico studies, and antiproliferative evaluation
por: Taghour, Mohammed S., et al.
Publicado: (2022)

New benzoxazole derivatives as potential VEGFR-2 inhibitors and apoptosis inducers: design, synthesis, anti-proliferative evaluation, flowcytometric analysis, and in silico studies
por: Elkady, Hazem, et al.
Publicado: (2021)

Synthesis, biological evaluation and computer-aided discovery of new thiazolidine-2,4-dione derivatives as potential antitumor VEGFR-2 inhibitors
por: Elkady, Hazem, et al.
Publicado: (2023)

Modified Benzoxazole-Based VEGFR-2 Inhibitors and Apoptosis Inducers: Design, Synthesis, and Anti-Proliferative Evaluation
por: Elwan, Alaa, et al.
Publicado: (2022)

Synthesis, anti-inflammatory, cytotoxic, and COX-1/2 inhibitory activities of cyclic imides bearing 3-benzenesulfonamide, oxime, and β-phenylalanine scaffolds: a molecular docking study
por: Abdel-Aziz, Alaa A.-M., et al.
Publicado: (2020)

Mechanistic interaction study of 5,6-Dichloro-2-[2-(pyridin-2-yl)ethyl]isoindoline-1,3-dione with bovine serum albumin by spectroscopic and molecular docking approaches
por: Alanazi, Mohammed M., et al.
Publicado: (2019)

Design, Synthesis, In Silico and In Vitro Studies of New Immunomodulatory Anticancer Nicotinamide Derivatives Targeting VEGFR-2
por: Yousef, Reda G., et al.
Publicado: (2022)

Design and synthesis of thiazolidine-2,4-diones hybrids with 1,2-dihydroquinolones and 2-oxindoles as potential VEGFR-2 inhibitors: in-vitro anticancer evaluation and in-silico studies
por: Taghour, Mohammed S., et al.
Publicado: (2022)

Synthesis, anticancer, apoptosis-inducing activities and EGFR and VEGFR2 assay mechanistic studies of 5,5-diphenylimidazolidine-2,4-dione derivatives: Molecular docking studies
por: Alkahtani, Hamad M., et al.
Publicado: (2019)

Anti-cancer and immunomodulatory evaluation of new nicotinamide derivatives as potential VEGFR-2 inhibitors and apoptosis inducers: in vitro and in silico studies
por: Yousef, Reda G., et al.
Publicado: (2022)

1-Benzyl-3-methylquinoxalin-2(1H)-one
por: Ramli, Youssef, et al.
Publicado: (2010)

2-Isopropyl-3-methylquinoxaline 1,4-dioxide
por: Li, Jian-Ye, et al.
Publicado: (2010)

1-Ethyl-3-methylquinoxalin-2(1H)-one
por: Benzeid, Hanane, et al.
Publicado: (2008)

N′-(3-Methylquinoxalin-2-yl)-N′-phenylbenzohydrazide
por: Ramli, Youssef, et al.
Publicado: (2011)

Network Pharmacology- and Molecular Docking-Based Identification of Potential Phytocompounds from Argyreia capitiformis in the Treatment of Inflammation
por: Obaidullah, Ahmad J., et al.
Publicado: (2022)

Investigation of Novel Benzoxazole-Oxadiazole Derivatives as Effective Anti-Alzheimer’s Agents: In Vitro and In Silico Approaches
por: Anwar, Saeed, et al.
Publicado: (2023)

Immunoinformatics-guided design of a multi-epitope vaccine based on the structural proteins of severe acute respiratory syndrome coronavirus 2
por: Obaidullah, Ahmad J., et al.
Publicado: (2021)

Design, synthesis, molecular modeling and biological evaluation of novel Benzoxazole-Benzamide conjugates via a 2-Thioacetamido linker as potential anti-proliferative agents, VEGFR-2 inhibitors and apoptotic inducers
por: Eissa, Ibrahim H., et al.
Publicado: (2022)

Design, synthesis, anticancer evaluation, and in silico ADMET analysis of novel thalidomide analogs as promising immunomodulatory agents
por: Kotb, Anas Ramadan, et al.
Publicado: (2023)

Validated Microwell-Based Spectrofluorimetric Method for Quantification of Ravidasvir (New Anti-Chronic Hepatitis C Virus-GT4) in Rat Plasma and Its Application to Pharmacokinetic Study
por: Hefnawy, Mohamed, et al.
Publicado: (2020)

Design, Synthesis, and Biological Evaluation of 2-Mercaptobenzoxazole Derivatives as Potential Multi-Kinase Inhibitors
por: Alanazi, Mohammed M., et al.
Publicado: (2023)

3-Methylquinoxaline-2-carboxylic acid 4-oxide monohydrate
por: Li, Yubo, et al.
Publicado: (2010)

In Silico Studies of Some Isoflavonoids as Potential Candidates against COVID-19 Targeting Human ACE2 (hACE2) and Viral Main Protease (M(pro))
por: Alesawy, Mohamed S., et al.
Publicado: (2021)

Design, synthesis, in silico studies, and biological evaluation of novel pyrimidine-5-carbonitrile derivatives as potential anti-proliferative agents, VEGFR-2 inhibitors and apoptotic inducers
por: Saleh, Abdulrahman M., et al.
Publicado: (2023)

New quinoline and isatin derivatives as apoptotic VEGFR-2 inhibitors: design, synthesis, anti-proliferative activity, docking, ADMET, toxicity, and MD simulation studies
por: Elkaeed, Eslam B., et al.
Publicado: (2022)

Design, synthesis, anti-proliferative evaluation, docking, and MD simulations studies of new thiazolidine-2,4-diones targeting VEGFR-2 and apoptosis pathway
por: Taghour, Mohammed S., et al.
Publicado: (2022)

Synthesis, potential antitumor activity, cell cycle analysis, and multitarget mechanisms of novel hydrazones incorporating a 4-methylsulfonylbenzene scaffold: a molecular docking study
por: Abdel-Aziz, Alaa A.-M., et al.
Publicado: (2021)

Design and Synthesis of New Quinoxaline Derivatives as Potential Histone Deacetylase Inhibitors Targeting Hepatocellular Carcinoma: In Silico, In Vitro, and SAR Studies
por: Ma, Chao, et al.
Publicado: (2021)

Design, synthesis, anti-proliferative evaluation, docking, and MD simulation studies of new thieno[2,3-d]pyrimidines targeting VEGFR-2
por: El-Metwally, Souad A., et al.
Publicado: (2023)

Antiproliferative Activity, Multikinase Inhibition, Apoptosis- Inducing Effects and Molecular Docking of Novel Isatin–Purine Hybrids
por: Alanazi, Ashwag S., et al.
Publicado: (2023)

Design, synthesis, antitumor evaluation, and molecular docking of novel pyrrolo[2,3-d]pyrimidine as multi-kinase inhibitors
por: Alanazi, Ashwag S., et al.
Publicado: (2023)

Albendazole repurposing on VEGFR-2 for possible anticancer application: In-silico analysis
por: Gaikwad, Nikita Maruti, et al.
Publicado: (2023)

A Theobromine Derivative with Anticancer Properties Targeting VEGFR‐2: Semisynthesis, in silico and in vitro Studies
por: Eissa, Ibrahim H., et al.
Publicado: (2023)

Deeper Insights on Cnesmone javanica Blume Leaves Extract: Chemical Profiles, Biological Attributes, Network Pharmacology and Molecular Docking
por: Obaidullah, Ahmad J., et al.
Publicado: (2021)

In Silico Discovery of Potential VEGFR-2 Inhibitors from Natural Derivatives for Anti-Angiogenesis Therapy
por: Li, Jing, et al.
Publicado: (2014)

In Vitro Evaluation and Bioinformatics Analysis of Schiff Bases Bearing Pyrazole Scaffold as Bioactive Agents: Antioxidant, Anti-Diabetic, Anti-Alzheimer, and Anti-Arthritic
por: Alkahtani, Hamad M., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_ridp7n9g8enrjkd0926qu5k482