Transformation of Polycythemia Vera to Pure Erythroid Leukemia

Pure erythroid leukemia (PEL) is an aggressive and exceedingly rare form of acute leukemia characterized as a neoplastic proliferation of immature cells committed to the erythroid lineage. It has a poor overall median survival of two to three months. To our knowledge, there are currently only a hand...

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Autores principales: Liu, Louisa, Dudheker, Neil, Sumarriva Lezama, Lhara M, Shah, Sameer, Nwaokoro, Maureen, Ranpura, Vishal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Pathology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8330807/
https://www.ncbi.nlm.nih.gov/pubmed/34367778
http://dx.doi.org/10.7759/cureus.16168
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author Liu, Louisa
Dudheker, Neil
Sumarriva Lezama, Lhara M
Shah, Sameer
Nwaokoro, Maureen
Ranpura, Vishal
author_facet Liu, Louisa
Dudheker, Neil
Sumarriva Lezama, Lhara M
Shah, Sameer
Nwaokoro, Maureen
Ranpura, Vishal
author_sort Liu, Louisa
collection PubMed
description Pure erythroid leukemia (PEL) is an aggressive and exceedingly rare form of acute leukemia characterized as a neoplastic proliferation of immature cells committed to the erythroid lineage. It has a poor overall median survival of two to three months. To our knowledge, there are currently only a handful of reports of PEL arising from polycythemia vera. Most reported cases have been associated with radiation therapy or chemotherapeutic alkylating agents. Here we report a rare occurrence of polycythemia vera treated with phlebotomy and hydroxyurea that underwent leukemic transformation to pure erythroid leukemia. 
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spelling pubmed-83308072021-08-06 Transformation of Polycythemia Vera to Pure Erythroid Leukemia Liu, Louisa Dudheker, Neil Sumarriva Lezama, Lhara M Shah, Sameer Nwaokoro, Maureen Ranpura, Vishal Cureus Pathology Pure erythroid leukemia (PEL) is an aggressive and exceedingly rare form of acute leukemia characterized as a neoplastic proliferation of immature cells committed to the erythroid lineage. It has a poor overall median survival of two to three months. To our knowledge, there are currently only a handful of reports of PEL arising from polycythemia vera. Most reported cases have been associated with radiation therapy or chemotherapeutic alkylating agents. Here we report a rare occurrence of polycythemia vera treated with phlebotomy and hydroxyurea that underwent leukemic transformation to pure erythroid leukemia.  Cureus 2021-07-04 /pmc/articles/PMC8330807/ /pubmed/34367778 http://dx.doi.org/10.7759/cureus.16168 Text en Copyright © 2021, Liu et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Pathology
Liu, Louisa
Dudheker, Neil
Sumarriva Lezama, Lhara M
Shah, Sameer
Nwaokoro, Maureen
Ranpura, Vishal
Transformation of Polycythemia Vera to Pure Erythroid Leukemia
title Transformation of Polycythemia Vera to Pure Erythroid Leukemia
title_full Transformation of Polycythemia Vera to Pure Erythroid Leukemia
title_fullStr Transformation of Polycythemia Vera to Pure Erythroid Leukemia
title_full_unstemmed Transformation of Polycythemia Vera to Pure Erythroid Leukemia
title_short Transformation of Polycythemia Vera to Pure Erythroid Leukemia
title_sort transformation of polycythemia vera to pure erythroid leukemia
topic Pathology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8330807/
https://www.ncbi.nlm.nih.gov/pubmed/34367778
http://dx.doi.org/10.7759/cureus.16168
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