Nurr1 repression mediates cardinal features of Parkinson’s disease in α-synuclein transgenic mice

Duplication/triplication mutations of the SNCA locus, encoding alpha-synuclein (ASYN), and loss of function mutations in Nurr1, a nuclear receptor guiding midbrain dopaminergic neuron development, are associated with familial Parkinson’s disease (PD). As we age, the expression levels of these two ge...

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Detalles Bibliográficos
Autores principales: Argyrofthalmidou, Maria, Spathis, Athanasios D, Maniati, Matina, Poula, Amalia, Katsianou, Maira A, Sotiriou, Evangelos, Manousaki, Maria, Perier, Celine, Papapanagiotou, Ioanna, Papadopoulou-Daifoti, Zeta, Pitychoutis, Pothitos M, Alexakos, Pavlos, Vila, Miquel, Stefanis, Leonidas, Vassilatis, Demetrios K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
General Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8330896/
https://www.ncbi.nlm.nih.gov/pubmed/33902111
http://dx.doi.org/10.1093/hmg/ddab118

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