The number of the CTCF binding sites of the H19/IGF2:IG-DMR correlates with DNA methylation and expression imprinting in a humanized mouse model

The reciprocal parent of origin-specific expression of H19 and IGF2 is controlled by the H19/IGF2:IG-DMR (IC1), whose maternal allele is unmethylated and acts as a CTCF-dependent insulator. In humans, internal IC1 deletions are associated with Beckwith–Wiedemann syndrome (BWS) and Silver-Russell syn...

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Detalles Bibliográficos
Autores principales: Freschi, Andrea, Del Prete, Rosita, Pignata, Laura, Cecere, Francesco, Manfrevola, Francesco, Mattia, Monica, Cobellis, Gilda, Sparago, Angela, Bartolomei, Marisa S, Riccio, Andrea, Cerrato, Flavia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
General Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8330897/
https://www.ncbi.nlm.nih.gov/pubmed/34132339
http://dx.doi.org/10.1093/hmg/ddab132

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