Cargando…

Miltefosine enhances infectivity of a miltefosine-resistant Leishmania infantum strain by attenuating its innate immune recognition

BACKGROUND: Miltefosine (MIL) is currently the only oral drug available to treat visceral leishmaniasis but its use as first-line monotherapy has been compromised by an increasing treatment failure. Despite the scarce number of resistant clinical isolates, MIL-resistance by mutations in a single ami...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bulté, Dimitri, Van Bockstal, Lieselotte, Dirkx, Laura, Van den Kerkhof, Magali, De Trez, Carl, Timmermans, Jean-Pierre, Hendrickx, Sarah, Maes, Louis, Caljon, Guy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8330912/ https://www.ncbi.nlm.nih.gov/pubmed/34292975 http://dx.doi.org/10.1371/journal.pntd.0009622

Ejemplares similares

Impact of clinically acquired miltefosine resistance by Leishmania infantum on mouse and sand fly infection
por: Van Bockstal, Lieselotte, et al.
Publicado: (2020)

Phenotypic adaptations of Leishmania donovani to recurrent miltefosine exposure and impact on sand fly infection
por: Hendrickx, Sarah, et al.
Publicado: (2020)

Combined treatment of miltefosine and paromomycin delays the onset of experimental drug resistance in Leishmania infantum
por: Hendrickx, Sarah, et al.
Publicado: (2017)

Immunosuppression of Syrian golden hamsters accelerates relapse but not the emergence of resistance in Leishmania infantum following recurrent miltefosine pressure
por: Hendrickx, S., et al.
Publicado: (2018)

Impaired development of a miltefosine-resistant Leishmania infantum strain in the sand fly vectors Phlebotomus perniciosus and Lutzomyia longipalpis
por: Van Bockstal, Lieselotte, et al.
Publicado: (2019)

Interferon Alpha Favors Macrophage Infection by Visceral Leishmania Species Through Upregulation of Sialoadhesin Expression
por: Van Bockstal, Lieselotte, et al.
Publicado: (2020)

Mitochondrial Proteomics of Antimony and Miltefosine Resistant Leishmania infantum
por: Vincent, Isabel M., et al.
Publicado: (2015)

Increased Leishmania infantum resistance to miltefosine and amphotericin B after treatment of a dog with miltefosine and allopurinol
por: Gonçalves, Gustavo, et al.
Publicado: (2021)

New insights with miltefosine unresponsiveness in Brazilian Leishmania infantum isolates
por: Bhattacharya, Arijit, et al.
Publicado: (2018)

Genomic and Molecular Characterization of Miltefosine Resistance in Leishmania infantum Strains with Either Natural or Acquired Resistance through Experimental Selection of Intracellular Amastigotes
por: Mondelaers, Annelies, et al.
Publicado: (2016)

Use of miltefosine to treat canine visceral leishmaniasis caused by Leishmania infantum in Brazil
por: dos Santos Nogueira, Fabio, et al.
Publicado: (2019)

In-Depth Quantitative Proteomics Characterization of In Vitro Selected Miltefosine Resistance in Leishmania infantum
por: Saboia-Vahia, Leonardo, et al.
Publicado: (2022)

3′Nucleotidase/nuclease is required for Leishmania infantum clinical isolate susceptibility to miltefosine
por: Carnielli, Juliana B.T., et al.
Publicado: (2022)

Effect of Clindamycin on Intestinal Microbiome and Miltefosine Pharmacology in Hamsters Infected with Leishmania infantum
por: Olías-Molero, Ana Isabel, et al.
Publicado: (2023)

Miltefosine-Lopinavir Combination Therapy Against Leishmania infantum Infection: In vitro and in vivo Approaches
por: Rebello, Karina M., et al.
Publicado: (2019)

A Leishmania infantum genetic marker associated with miltefosine treatment failure for visceral leishmaniasis
por: Carnielli, Juliana B.T., et al.
Publicado: (2018)

In-depth comparison of cell-based methodological approaches to determine drug susceptibility of visceral Leishmania isolates
por: Hendrickx, Sarah, et al.
Publicado: (2019)

Resolution of tongue lesions caused by Leishmania infantum in a dog treated with the association miltefosine-allopurinol
por: Foglia Manzillo, Valentina, et al.
Publicado: (2009)

Untargeted metabolomic analysis of miltefosine action in Leishmania infantum reveals changes to the internal lipid metabolism()
por: Vincent, Isabel M., et al.
Publicado: (2013)

Natural Resistance of Leishmania infantum to Miltefosine Contributes to the Low Efficacy in the Treatment of Visceral Leishmaniasis in Brazil
por: Carnielli, Juliana B. T., et al.
Publicado: (2019)

Downregulation of FeSOD-A expression in Leishmania infantum alters trivalent antimony and miltefosine susceptibility
por: Santi, Ana Maria Murta, et al.
Publicado: (2021)

Leishmania Resistance to Miltefosine Associated with Genetic Marker
por: Cojean, Sandrine, et al.
Publicado: (2012)

Generation of Luciferase-Expressing Leishmania infantum chagasi and Assessment of Miltefosine Efficacy in Infected Hamsters through Bioimaging
por: Reimão, Juliana Q., et al.
Publicado: (2015)

Fitness and Phenotypic Characterization of Miltefosine-Resistant Leishmania major
por: Turner, Kimbra G., et al.
Publicado: (2015)

Complex cutaneous infection by Leishmania mexicana treated with miltefosine
por: Sadowsky, Rachel L., et al.
Publicado: (2022)

In Vitro Susceptibility to Miltefosine of Leishmania infantum (syn. L. chagasi) Isolates from Different Geographical Areas in Brazil
por: Espada, Caroline Ricce, et al.
Publicado: (2021)

No evidence for cardiotoxicity of miltefosine()
por: Dorlo, Thomas P.C.
Publicado: (2022)

No evidence for cardiotoxicity of miltefosine – Reply()
por: Barroso, Daniel Holanda, et al.
Publicado: (2022)

Miltefosine-Induced Apoptotic Cell Death on Leishmania major and L. tropica Strains
por: Khademvatan, Shahram, et al.
Publicado: (2011)

Ascorbic acid reduces the genetic damage caused by miltefosine (hexadecylphosphocholine) in animals infected by Leishmania (Leishamnia) infantum without decreasing its antileishmanial activity
por: Castelo-Branco, Patrícia Valéria, et al.
Publicado: (2018)

The effect of the sugar metabolism on Leishmania infantum promastigotes inside the gut of Lutzomyia longipalpis: A sweet relationship?
por: Hendrickx, Sarah, et al.
Publicado: (2022)

Oral miltefosine for refractory Acanthamoeba keratitis
por: Hirabayashi, Kristin E., et al.
Publicado: (2019)

Repurposing of Miltefosine as an Adjuvant for Influenza Vaccine
por: Lu, Lu, et al.
Publicado: (2020)

Miltefosine for the treatment of cutaneous leishmaniasis—A pilot study from Ethiopia
por: van Henten, Saskia, et al.
Publicado: (2021)

Evaluation of a pan-Leishmania SL RNA qPCR assay for parasite detection in laboratory-reared and field-collected sand flies and reservoir hosts
por: Pareyn, Myrthe, et al.
Publicado: (2020)

Leishmania Promastigotes Lack Phosphatidylserine but Bind Annexin V upon Permeabilization or Miltefosine Treatment
por: Weingärtner, Adrien, et al.
Publicado: (2012)

Pharmacodynamics and cellular accumulation of amphotericin B and miltefosine in Leishmania donovani-infected primary macrophages
por: Voak, Andrew A, et al.
Publicado: (2018)

Resistance of Leishmania (Viannia) Panamensis to Meglumine Antimoniate or Miltefosine Modulates Neutrophil Effector Functions
por: Regli, Ivo B., et al.
Publicado: (2018)

Miltefosine and Nifuratel Combination: A Promising Therapy for the Treatment of Leishmania donovani Visceral Leishmaniasis
por: Melcon-Fernandez, Estela, et al.
Publicado: (2023)

SUCCESSFUL TREATMENT OF MULTIFOCAL CUTANEOUS LEISHMANIASIS WITH MILTEFOSINE
por: Madke, Bhushan, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_qdcbmpiarat941j0npdgm3tua9