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Estimating heritability and its enrichment in tissue-specific gene sets in admixed populations

It is important to study the genetics of complex traits in diverse populations. Here, we introduce covariate-adjusted linkage disequilibrium (LD) score regression (cov-LDSC), a method to estimate SNP-heritability ([Formula: see text] and its enrichment in homogenous and admixed populations with summ...

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Detalles Bibliográficos
Autores principales:	Luo, Yang, Li, Xinyi, Wang, Xin, Gazal, Steven, Mercader, Josep Maria, Neale, Benjamin M, Florez, Jose C, Auton, Adam, Price, Alkes L, Finucane, Hilary K, Raychaudhuri, Soumya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	General Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8330913/ https://www.ncbi.nlm.nih.gov/pubmed/33987664 http://dx.doi.org/10.1093/hmg/ddab130

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