Mitochondrial RNase H1 activity regulates R-loop homeostasis to maintain genome integrity and enable early embryogenesis in Arabidopsis

Plant mitochondrial genomes undergo frequent homologous recombination (HR). Ectopic HR activity is inhibited by the HR surveillance pathway, but the underlying regulatory mechanism is unclear. Here, we show that the mitochondrial RNase H1 AtRNH1B impairs the formation of RNA:DNA hybrids (R-loops) an...

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Detalles Bibliográficos
Autores principales: Cheng, Lingling, Wang, Wenjie, Yao, Yao, Sun, Qianwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8330923/
https://www.ncbi.nlm.nih.gov/pubmed/34343166
http://dx.doi.org/10.1371/journal.pbio.3001357

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8330923/
https://www.ncbi.nlm.nih.gov/pubmed/34343166
http://dx.doi.org/10.1371/journal.pbio.3001357

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