Association of PIK3CA mutation and PTEN loss with expression of CD274 (PD-L1) in colorectal carcinoma

Immunotherapy targeting the CD274 (PD-L1)/PDCD1 (PD-1) immune checkpoint axis has emerged as a promising treatment strategy for various cancers. Experimental evidence suggests that phosphatidylinositol-4,5-bisphosphonate 3-kinase (PI3K) signaling may upregulate CD274 expression. Thus, we hypothesize...

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Detalles Bibliográficos
Autores principales: Ugai, Tomotaka, Zhao, Melissa, Shimizu, Takashi, Akimoto, Naohiko, Shi, Shanshan, Takashima, Yasutoshi, Zhong, Rong, Lau, Mai Chan, Haruki, Koichiro, Arima, Kota, Fujiyoshi, Kenji, Langworthy, Benjamin, Masugi, Yohei, da Silva, Annacarolina, Nosho, Katsuhiko, Baba, Yoshifumi, Song, Mingyang, Chan, Andrew T., Wang, Molin, Meyerhardt, Jeffrey A., Giannakis, Marios, Väyrynen, Juha P., Nowak, Jonathan A., Ogino, Shuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8331006/
https://www.ncbi.nlm.nih.gov/pubmed/34377593
http://dx.doi.org/10.1080/2162402X.2021.1956173

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