A matrix of structure-based designs yields improved VRC01-class antibodies for HIV-1 therapy and prevention

Passive transfer of broadly neutralizing antibodies is showing promise in the treatment and prevention of HIV-1. One class of antibodies, the VRC01 class, appears especially promising. To improve VRC01-class antibodies, we combined structure-based design with a matrix-based approach to generate VRC0...

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Detalles Bibliográficos
Autores principales: Kwon, Young D., Asokan, Mangaiarkarasi, Gorman, Jason, Zhang, Baoshan, Liu, Qingbo, Louder, Mark K., Lin, Bob C., McKee, Krisha, Pegu, Amarendra, Verardi, Raffaello, Yang, Eun Sung, Program, VRC Production, Carlton, Kevin, Doria-Rose, Nicole A., Lusso, Paolo, Mascola, John R., Kwong, Peter D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8331036/
https://www.ncbi.nlm.nih.gov/pubmed/34328065
http://dx.doi.org/10.1080/19420862.2021.1946918

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