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Manipulating the exposome to enable better ageing

The sum total of life course exposures creates an exposome that has a significant impact on age-related health. Understanding the interplay between exposome factors and the (epi) genome, offers pertinent insights into the ageing process and its relationship with the accumulation of allostatic load....

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Autores principales: Shiels, Paul G., Painer, Johanna, Natterson-Horowitz, Barbara, Johnson, Richard J., Miranda, Jaime J., Stenvinkel, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8331090/
https://www.ncbi.nlm.nih.gov/pubmed/34319404
http://dx.doi.org/10.1042/BCJ20200958
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author Shiels, Paul G.
Painer, Johanna
Natterson-Horowitz, Barbara
Johnson, Richard J.
Miranda, Jaime J.
Stenvinkel, Peter
author_facet Shiels, Paul G.
Painer, Johanna
Natterson-Horowitz, Barbara
Johnson, Richard J.
Miranda, Jaime J.
Stenvinkel, Peter
author_sort Shiels, Paul G.
collection PubMed
description The sum total of life course exposures creates an exposome that has a significant impact on age-related health. Understanding the interplay between exposome factors and the (epi) genome, offers pertinent insights into the ageing process and its relationship with the accumulation of allostatic load. We propose to exploit this to develop a biomimetic approach that will provide insight into how evolution through natural selection in other species has solved many age related human health issues. In particular, we will emphasise the need to reconnect a more mechanistic approach to medical science with a broader natural sciences approach, using biomimetics to mitigate the global burden of age related ill health. In particular, we will discuss how such an approach indicates leverage of the activities of the Nrf 2 gene to enhance health span via reintroduction of the classical ‘Food as Medicine’ concept, including modulation of the microbiome and the creation of more salutogenic and biophilic environments. Additionally, we will discuss how this approach integrates with novel and developing senotherapies.
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spelling pubmed-83310902021-08-11 Manipulating the exposome to enable better ageing Shiels, Paul G. Painer, Johanna Natterson-Horowitz, Barbara Johnson, Richard J. Miranda, Jaime J. Stenvinkel, Peter Biochem J Aging The sum total of life course exposures creates an exposome that has a significant impact on age-related health. Understanding the interplay between exposome factors and the (epi) genome, offers pertinent insights into the ageing process and its relationship with the accumulation of allostatic load. We propose to exploit this to develop a biomimetic approach that will provide insight into how evolution through natural selection in other species has solved many age related human health issues. In particular, we will emphasise the need to reconnect a more mechanistic approach to medical science with a broader natural sciences approach, using biomimetics to mitigate the global burden of age related ill health. In particular, we will discuss how such an approach indicates leverage of the activities of the Nrf 2 gene to enhance health span via reintroduction of the classical ‘Food as Medicine’ concept, including modulation of the microbiome and the creation of more salutogenic and biophilic environments. Additionally, we will discuss how this approach integrates with novel and developing senotherapies. Portland Press Ltd. 2021-07-30 2021-07-28 /pmc/articles/PMC8331090/ /pubmed/34319404 http://dx.doi.org/10.1042/BCJ20200958 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Aging
Shiels, Paul G.
Painer, Johanna
Natterson-Horowitz, Barbara
Johnson, Richard J.
Miranda, Jaime J.
Stenvinkel, Peter
Manipulating the exposome to enable better ageing
title Manipulating the exposome to enable better ageing
title_full Manipulating the exposome to enable better ageing
title_fullStr Manipulating the exposome to enable better ageing
title_full_unstemmed Manipulating the exposome to enable better ageing
title_short Manipulating the exposome to enable better ageing
title_sort manipulating the exposome to enable better ageing
topic Aging
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8331090/
https://www.ncbi.nlm.nih.gov/pubmed/34319404
http://dx.doi.org/10.1042/BCJ20200958
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