Reconstitution of human CMG helicase ubiquitylation by CUL2(LRR1) and multiple E2 enzymes

Cullin ubiquitin ligases drive replisome disassembly during DNA replication termination. In worm, frog and mouse cells, CUL2(LRR1) is required to ubiquitylate the MCM7 subunit of the CMG helicase. Here, we show that cullin ligases also drive CMG-MCM7 ubiquitylation in human cells, thereby making the...

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Detalles Bibliográficos
Autores principales: Le, Thanh Thi, Ainsworth, Johanna, Polo Rivera, Cristian, Macartney, Thomas, Labib, Karim P.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2021
Materias:
DNA, Chromosomes & Chromosomal Structure
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8331092/
https://www.ncbi.nlm.nih.gov/pubmed/34195792
http://dx.doi.org/10.1042/BCJ20210315

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8331092/
https://www.ncbi.nlm.nih.gov/pubmed/34195792
http://dx.doi.org/10.1042/BCJ20210315

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