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Reconstitution of human CMG helicase ubiquitylation by CUL2(LRR1) and multiple E2 enzymes
Cullin ubiquitin ligases drive replisome disassembly during DNA replication termination. In worm, frog and mouse cells, CUL2(LRR1) is required to ubiquitylate the MCM7 subunit of the CMG helicase. Here, we show that cullin ligases also drive CMG-MCM7 ubiquitylation in human cells, thereby making the...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Portland Press Ltd.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8331092/ https://www.ncbi.nlm.nih.gov/pubmed/34195792 http://dx.doi.org/10.1042/BCJ20210315 |