New Approach Methodology for Assessing Inhalation Risks of a Contact Respiratory Cytotoxicant: Computational Fluid Dynamics-Based Aerosol Dosimetry Modeling for Cross-Species and In Vitro Comparisons

Regulatory agencies are considering alternative approaches to assessing inhalation toxicity that utilizes in vitro studies with human cells and in silico modeling in lieu of additional animal studies. In support of this goal, computational fluid-particle dynamics models were developed to estimate si...

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Detalles Bibliográficos
Autores principales: Corley, Richard A, Kuprat, Andrew P, Suffield, Sarah R, Kabilan, Senthil, Hinderliter, Paul M, Yugulis, Kevin, Ramanarayanan, Tharacad S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Emerging Technologies, Methods, and Models
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8331159/
https://www.ncbi.nlm.nih.gov/pubmed/34077545
http://dx.doi.org/10.1093/toxsci/kfab062

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