Instability in NAD(+) metabolism leads to impaired cardiac mitochondrial function and communication

Poly(ADP-ribose) polymerase (PARP) enzymes initiate (mt)DNA repair mechanisms and use nicotinamide adenine dinucleotide (NAD(+)) as energy source. Prolonged PARP activity can drain cellular NAD(+) reserves, leading to de-regulation of important molecular processes. Here, we provide evidence of a pat...

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Detalles Bibliográficos
Autores principales: Lauritzen, Knut H, Olsen, Maria Belland, Ahmed, Mohammed Shakil, Yang, Kuan, Rinholm, Johanne Egge, Bergersen, Linda H, Esbensen, Qin Ying, Sverkeli, Lars Jansen, Ziegler, Mathias, Attramadal, Håvard, Halvorsen, Bente, Aukrust, Pål, Yndestad, Arne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8331182/
https://www.ncbi.nlm.nih.gov/pubmed/34343089
http://dx.doi.org/10.7554/eLife.59828

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