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Oxaliplatin resistance in colorectal cancer enhances TRAIL sensitivity via death receptor 4 upregulation and lipid raft localization

Colorectal cancer (CRC) remains a leading cause of cancer death, and its mortality is associated with metastasis and chemoresistance. We demonstrate that oxaliplatin-resistant CRC cells are sensitized to TRAIL-mediated apoptosis. Oxaliplatin-resistant cells exhibited transcriptional downregulation o...

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Detalles Bibliográficos
Autores principales:	Greenlee, Joshua D, Lopez-Cavestany, Maria, Ortiz-Otero, Nerymar, Liu, Kevin, Subramanian, Tejas, Cagir, Burt, King, Michael R
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2021
Materias:	Cancer Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8331188/ https://www.ncbi.nlm.nih.gov/pubmed/34342264 http://dx.doi.org/10.7554/eLife.67750

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