Pharmacological rescue of impaired mitophagy in Parkinson’s disease-related LRRK2 G2019S knock-in mice

Parkinson’s disease (PD) is a major and progressive neurodegenerative disorder, yet the biological mechanisms involved in its aetiology are poorly understood. Evidence links this disorder with mitochondrial dysfunction and/or impaired lysosomal degradation – key features of the autophagy of mitochon...

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Detalles Bibliográficos
Autores principales: Singh, Francois, Prescott, Alan R, Rosewell, Philippa, Ball, Graeme, Reith, Alastair D, Ganley, Ian G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8331189/
https://www.ncbi.nlm.nih.gov/pubmed/34340748
http://dx.doi.org/10.7554/eLife.67604

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8331189/
https://www.ncbi.nlm.nih.gov/pubmed/34340748
http://dx.doi.org/10.7554/eLife.67604

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