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Diabetes and the risk of hospitalisation for infection: the Atherosclerosis Risk in Communities (ARIC) study
AIMS/HYPOTHESIS: The aim of this work was to assess the association between diabetes and risk for infection-related hospitalisation and mortality. METHODS: We conducted a prospective cohort analysis of the Atherosclerosis Risk in Communities (ARIC) study. Diabetes was defined as a fasting glucose ≥7...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Springer Berlin Heidelberg
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8331324/ https://www.ncbi.nlm.nih.gov/pubmed/34345973 http://dx.doi.org/10.1007/s00125-021-05522-3 |
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author | Fang, Michael Ishigami, Junichi Echouffo-Tcheugui, Justin B. Lutsey, Pamela L. Pankow, James S. Selvin, Elizabeth |
author_facet | Fang, Michael Ishigami, Junichi Echouffo-Tcheugui, Justin B. Lutsey, Pamela L. Pankow, James S. Selvin, Elizabeth |
author_sort | Fang, Michael |
collection | PubMed |
description | AIMS/HYPOTHESIS: The aim of this work was to assess the association between diabetes and risk for infection-related hospitalisation and mortality. METHODS: We conducted a prospective cohort analysis of the Atherosclerosis Risk in Communities (ARIC) study. Diabetes was defined as a fasting glucose ≥7 mmol/l or non-fasting glucose ≥11.1 mmol/l, self-report of a diagnosis of diabetes by a physician, or current diabetes medication use. Hospitalisation for infection was ascertained from hospital discharge records. Participants were followed from 1987–1989 to 2019. RESULTS: We included 12,379 participants (mean age 54.5 years; 24.7% Black race; 54.3% female sex). During a median follow-up of 23.8 years, there were 4229 new hospitalisations for infection. After adjusting for potential confounders, people with (vs without) diabetes at baseline had a higher risk for hospitalisation for infection (HR 1.67 [95% CI 1.52, 1.83]). Results were generally consistent across infection type but the association was especially pronounced for foot infection (HR 5.99 [95% CI 4.38, 8.19]). Diabetes was more strongly associated with hospitalisation for infection in younger participants and Black people. Overall infection mortality was low (362 deaths due to infection) but the adjusted risk was increased for people with diabetes (HR 1.72 [95% CI 1.28, 2.31]). CONCLUSIONS/INTERPRETATION: Diabetes confers significant risk for infection-related hospitalisation. Enhancing prevention and early treatment of infection in those with diabetes is needed to reduce infection-related morbidity and mortality. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version of this article (10.1007/s00125-021-05522-3) contains peer-reviewed but unedited supplementary material. |
format | Online Article Text |
id | pubmed-8331324 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-83313242021-08-04 Diabetes and the risk of hospitalisation for infection: the Atherosclerosis Risk in Communities (ARIC) study Fang, Michael Ishigami, Junichi Echouffo-Tcheugui, Justin B. Lutsey, Pamela L. Pankow, James S. Selvin, Elizabeth Diabetologia Article AIMS/HYPOTHESIS: The aim of this work was to assess the association between diabetes and risk for infection-related hospitalisation and mortality. METHODS: We conducted a prospective cohort analysis of the Atherosclerosis Risk in Communities (ARIC) study. Diabetes was defined as a fasting glucose ≥7 mmol/l or non-fasting glucose ≥11.1 mmol/l, self-report of a diagnosis of diabetes by a physician, or current diabetes medication use. Hospitalisation for infection was ascertained from hospital discharge records. Participants were followed from 1987–1989 to 2019. RESULTS: We included 12,379 participants (mean age 54.5 years; 24.7% Black race; 54.3% female sex). During a median follow-up of 23.8 years, there were 4229 new hospitalisations for infection. After adjusting for potential confounders, people with (vs without) diabetes at baseline had a higher risk for hospitalisation for infection (HR 1.67 [95% CI 1.52, 1.83]). Results were generally consistent across infection type but the association was especially pronounced for foot infection (HR 5.99 [95% CI 4.38, 8.19]). Diabetes was more strongly associated with hospitalisation for infection in younger participants and Black people. Overall infection mortality was low (362 deaths due to infection) but the adjusted risk was increased for people with diabetes (HR 1.72 [95% CI 1.28, 2.31]). CONCLUSIONS/INTERPRETATION: Diabetes confers significant risk for infection-related hospitalisation. Enhancing prevention and early treatment of infection in those with diabetes is needed to reduce infection-related morbidity and mortality. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version of this article (10.1007/s00125-021-05522-3) contains peer-reviewed but unedited supplementary material. Springer Berlin Heidelberg 2021-08-04 2021 /pmc/articles/PMC8331324/ /pubmed/34345973 http://dx.doi.org/10.1007/s00125-021-05522-3 Text en © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Article Fang, Michael Ishigami, Junichi Echouffo-Tcheugui, Justin B. Lutsey, Pamela L. Pankow, James S. Selvin, Elizabeth Diabetes and the risk of hospitalisation for infection: the Atherosclerosis Risk in Communities (ARIC) study |
title | Diabetes and the risk of hospitalisation for infection: the Atherosclerosis Risk in Communities (ARIC) study |
title_full | Diabetes and the risk of hospitalisation for infection: the Atherosclerosis Risk in Communities (ARIC) study |
title_fullStr | Diabetes and the risk of hospitalisation for infection: the Atherosclerosis Risk in Communities (ARIC) study |
title_full_unstemmed | Diabetes and the risk of hospitalisation for infection: the Atherosclerosis Risk in Communities (ARIC) study |
title_short | Diabetes and the risk of hospitalisation for infection: the Atherosclerosis Risk in Communities (ARIC) study |
title_sort | diabetes and the risk of hospitalisation for infection: the atherosclerosis risk in communities (aric) study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8331324/ https://www.ncbi.nlm.nih.gov/pubmed/34345973 http://dx.doi.org/10.1007/s00125-021-05522-3 |
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