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Measuring and interpreting pervasive heterogeneity, poikilosis

Measurements are widely used in science, engineering, industry, and trade. They form the basis for experimental scientific research, approach, and progress; however, their foundations are seldom thought or questioned. Recently poikilosis, pervasive heterogeneity ranging from subatomic level to biosp...

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Autor principal: Vihinen, Mauno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8332472/
https://www.ncbi.nlm.nih.gov/pubmed/34377957
http://dx.doi.org/10.1096/fba.2021-00015
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author Vihinen, Mauno
author_facet Vihinen, Mauno
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description Measurements are widely used in science, engineering, industry, and trade. They form the basis for experimental scientific research, approach, and progress; however, their foundations are seldom thought or questioned. Recently poikilosis, pervasive heterogeneity ranging from subatomic level to biosphere, was introduced. Poikilosis makes single point measurements and estimates obsolete and irrelevant as measurands display intervals of magnitudes. Consideration of poikilosis requires new lines of thinking in experimental design, conduction of studies, data analysis and interpretation. Measurements of poikilosis must consider lagom, normal, variation extent. Measurements, measures, and measurands as well as the measuring systems and uncertainties are discussed from the perspective of poikilosis. New systematics is introduced for description of uncertainty in measurements and for types of experimental designs. Poikilosis‐aware experimenting, data analysis and interpretation are discussed. Instructions are provided for how to measure lagom and non‐lagom effects of poikilosis. Consideration of poikilosis can solve scientific controversies and enigmas and can allow novel insight into systems, processes, mechanisms, and reactions and their interpretation, understanding, and manipulation. Furthermore, it will increase reproducibility of measurements and studies.
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spelling pubmed-83324722021-08-09 Measuring and interpreting pervasive heterogeneity, poikilosis Vihinen, Mauno FASEB Bioadv Methods Measurements are widely used in science, engineering, industry, and trade. They form the basis for experimental scientific research, approach, and progress; however, their foundations are seldom thought or questioned. Recently poikilosis, pervasive heterogeneity ranging from subatomic level to biosphere, was introduced. Poikilosis makes single point measurements and estimates obsolete and irrelevant as measurands display intervals of magnitudes. Consideration of poikilosis requires new lines of thinking in experimental design, conduction of studies, data analysis and interpretation. Measurements of poikilosis must consider lagom, normal, variation extent. Measurements, measures, and measurands as well as the measuring systems and uncertainties are discussed from the perspective of poikilosis. New systematics is introduced for description of uncertainty in measurements and for types of experimental designs. Poikilosis‐aware experimenting, data analysis and interpretation are discussed. Instructions are provided for how to measure lagom and non‐lagom effects of poikilosis. Consideration of poikilosis can solve scientific controversies and enigmas and can allow novel insight into systems, processes, mechanisms, and reactions and their interpretation, understanding, and manipulation. Furthermore, it will increase reproducibility of measurements and studies. John Wiley and Sons Inc. 2021-05-03 /pmc/articles/PMC8332472/ /pubmed/34377957 http://dx.doi.org/10.1096/fba.2021-00015 Text en ©2021 The Authors. FASEB BioAdvances published by The Federation of American Societies for Experimental Biology https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Methods
Vihinen, Mauno
Measuring and interpreting pervasive heterogeneity, poikilosis
title Measuring and interpreting pervasive heterogeneity, poikilosis
title_full Measuring and interpreting pervasive heterogeneity, poikilosis
title_fullStr Measuring and interpreting pervasive heterogeneity, poikilosis
title_full_unstemmed Measuring and interpreting pervasive heterogeneity, poikilosis
title_short Measuring and interpreting pervasive heterogeneity, poikilosis
title_sort measuring and interpreting pervasive heterogeneity, poikilosis
topic Methods
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8332472/
https://www.ncbi.nlm.nih.gov/pubmed/34377957
http://dx.doi.org/10.1096/fba.2021-00015
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