Transcriptional CDK inhibitors, CYC065 and THZ1 promote Bim-dependent apoptosis in primary and recurrent GBM through cell cycle arrest and Mcl-1 downregulation

Activation of cyclin-dependent kinases (CDKs) contributes to the uncontrolled proliferation of tumour cells. Genomic alterations that lead to the constitutive activation or overexpression of CDKs can support tumourigenesis including glioblastoma (GBM), the most common and aggressive primary brain tu...

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Detalles Bibliográficos
Autores principales: Juric, Viktorija, Hudson, Lance, Fay, Joanna, Richards, Cathy E., Jahns, Hanne, Verreault, Maïté, Bielle, Franck, Idbaih, Ahmed, Lamfers, Martine L. M., Hopkins, Ann M., Rehm, Markus, Murphy, Brona M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8333061/
https://www.ncbi.nlm.nih.gov/pubmed/34344865
http://dx.doi.org/10.1038/s41419-021-04050-7

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