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Probing subicular inputs to the medial prefrontal cortex
The hippocampal formation is anatomically and functionally divided into a dorsal and a ventral part, being involved in processing cognitive tasks and emotional stimuli, respectively. The ventral subiculum as part of the hippocampal formation projects to the medial prefrontal cortex (mPFC), but only...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8333156/ https://www.ncbi.nlm.nih.gov/pubmed/34381980 http://dx.doi.org/10.1016/j.isci.2021.102856 |
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author | Beerens, Sanne Vroman, Rozan Webster, Jack F. Wozny, Christian |
author_facet | Beerens, Sanne Vroman, Rozan Webster, Jack F. Wozny, Christian |
author_sort | Beerens, Sanne |
collection | PubMed |
description | The hippocampal formation is anatomically and functionally divided into a dorsal and a ventral part, being involved in processing cognitive tasks and emotional stimuli, respectively. The ventral subiculum as part of the hippocampal formation projects to the medial prefrontal cortex (mPFC), but only very little is known about connections arising from the dorsal SUB (dSUB). Here, we investigate the dSUB to mPFC connectivity in acute brain slices using electrophysiology and optogenetics. We show that the anterior cingulate cortex (ACC) is the main target of dorsal subicular projections to the mPFC, with no preference between excitatory or inhibitory neurons. In addition to superficial neurons in the ACC, the prelimbic and infralimbic PFC are also targeted by subicular fibers. Thus, these novel region- and layer-specific connections between the dSUB and the prefrontal cortices challenge existing anatomical data and refine the hippocampocortical wiring diagram. |
format | Online Article Text |
id | pubmed-8333156 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-83331562021-08-10 Probing subicular inputs to the medial prefrontal cortex Beerens, Sanne Vroman, Rozan Webster, Jack F. Wozny, Christian iScience Article The hippocampal formation is anatomically and functionally divided into a dorsal and a ventral part, being involved in processing cognitive tasks and emotional stimuli, respectively. The ventral subiculum as part of the hippocampal formation projects to the medial prefrontal cortex (mPFC), but only very little is known about connections arising from the dorsal SUB (dSUB). Here, we investigate the dSUB to mPFC connectivity in acute brain slices using electrophysiology and optogenetics. We show that the anterior cingulate cortex (ACC) is the main target of dorsal subicular projections to the mPFC, with no preference between excitatory or inhibitory neurons. In addition to superficial neurons in the ACC, the prelimbic and infralimbic PFC are also targeted by subicular fibers. Thus, these novel region- and layer-specific connections between the dSUB and the prefrontal cortices challenge existing anatomical data and refine the hippocampocortical wiring diagram. Elsevier 2021-07-10 /pmc/articles/PMC8333156/ /pubmed/34381980 http://dx.doi.org/10.1016/j.isci.2021.102856 Text en © 2021 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Beerens, Sanne Vroman, Rozan Webster, Jack F. Wozny, Christian Probing subicular inputs to the medial prefrontal cortex |
title | Probing subicular inputs to the medial prefrontal cortex |
title_full | Probing subicular inputs to the medial prefrontal cortex |
title_fullStr | Probing subicular inputs to the medial prefrontal cortex |
title_full_unstemmed | Probing subicular inputs to the medial prefrontal cortex |
title_short | Probing subicular inputs to the medial prefrontal cortex |
title_sort | probing subicular inputs to the medial prefrontal cortex |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8333156/ https://www.ncbi.nlm.nih.gov/pubmed/34381980 http://dx.doi.org/10.1016/j.isci.2021.102856 |
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