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Assessing the association of rs7574865 STAT4 gene variant and type 1 diabetes mellitus among Egyptian patients
BACKGROUND: Variants in the signal transducer and activator of transcription 4 (STAT4) gene have an important role in the incident of multiple autoimmune diseases including type 1 diabetes mellitus (T1D). It is a genetically related auto-immune disorder that resulted from T cell-mediated destruction...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8333174/ https://www.ncbi.nlm.nih.gov/pubmed/34342790 http://dx.doi.org/10.1186/s43141-021-00214-2 |
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author | Abdelmajed, Samar Samir El-Dessouky, Mohamed A. SalahElDin, Doaa S. Hassan, Naglaa Abu-Mandil Zaki, Moushira Erfan Ismail, Somaia |
author_facet | Abdelmajed, Samar Samir El-Dessouky, Mohamed A. SalahElDin, Doaa S. Hassan, Naglaa Abu-Mandil Zaki, Moushira Erfan Ismail, Somaia |
author_sort | Abdelmajed, Samar Samir |
collection | PubMed |
description | BACKGROUND: Variants in the signal transducer and activator of transcription 4 (STAT4) gene have an important role in the incident of multiple autoimmune diseases including type 1 diabetes mellitus (T1D). It is a genetically related auto-immune disorder that resulted from T cell-mediated destruction of pancreatic cells that are in control for the production of insulin in the blood. The current study aimed to clarify the role of STAT4 (rs7574865) variant allelic and genotypic variations in the susceptibility to type 1 diabetes among Egyptians by using the real-time PCR. RESULTS: A total of 100 patients and 100 controls were genotyped for rs7574865, and the biochemical and anthropometric parameters were measured to show that type 1 diabetic patients had significantly higher levels of HbA1c and triglycerides compared to non-diabetic individuals (P < 0.05). And genetically, the T allele and GT genotype have a significant correlation with diabetes type 1. CONCLUSION: It was confirmed by this study that the rs7574865 T allele and GT genotype have a significant correlation with diabetes type 1 incidence among Egyptian patients. |
format | Online Article Text |
id | pubmed-8333174 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-83331742021-08-20 Assessing the association of rs7574865 STAT4 gene variant and type 1 diabetes mellitus among Egyptian patients Abdelmajed, Samar Samir El-Dessouky, Mohamed A. SalahElDin, Doaa S. Hassan, Naglaa Abu-Mandil Zaki, Moushira Erfan Ismail, Somaia J Genet Eng Biotechnol Research BACKGROUND: Variants in the signal transducer and activator of transcription 4 (STAT4) gene have an important role in the incident of multiple autoimmune diseases including type 1 diabetes mellitus (T1D). It is a genetically related auto-immune disorder that resulted from T cell-mediated destruction of pancreatic cells that are in control for the production of insulin in the blood. The current study aimed to clarify the role of STAT4 (rs7574865) variant allelic and genotypic variations in the susceptibility to type 1 diabetes among Egyptians by using the real-time PCR. RESULTS: A total of 100 patients and 100 controls were genotyped for rs7574865, and the biochemical and anthropometric parameters were measured to show that type 1 diabetic patients had significantly higher levels of HbA1c and triglycerides compared to non-diabetic individuals (P < 0.05). And genetically, the T allele and GT genotype have a significant correlation with diabetes type 1. CONCLUSION: It was confirmed by this study that the rs7574865 T allele and GT genotype have a significant correlation with diabetes type 1 incidence among Egyptian patients. Springer Berlin Heidelberg 2021-08-03 /pmc/articles/PMC8333174/ /pubmed/34342790 http://dx.doi.org/10.1186/s43141-021-00214-2 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Research Abdelmajed, Samar Samir El-Dessouky, Mohamed A. SalahElDin, Doaa S. Hassan, Naglaa Abu-Mandil Zaki, Moushira Erfan Ismail, Somaia Assessing the association of rs7574865 STAT4 gene variant and type 1 diabetes mellitus among Egyptian patients |
title | Assessing the association of rs7574865 STAT4 gene variant and type 1 diabetes mellitus among Egyptian patients |
title_full | Assessing the association of rs7574865 STAT4 gene variant and type 1 diabetes mellitus among Egyptian patients |
title_fullStr | Assessing the association of rs7574865 STAT4 gene variant and type 1 diabetes mellitus among Egyptian patients |
title_full_unstemmed | Assessing the association of rs7574865 STAT4 gene variant and type 1 diabetes mellitus among Egyptian patients |
title_short | Assessing the association of rs7574865 STAT4 gene variant and type 1 diabetes mellitus among Egyptian patients |
title_sort | assessing the association of rs7574865 stat4 gene variant and type 1 diabetes mellitus among egyptian patients |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8333174/ https://www.ncbi.nlm.nih.gov/pubmed/34342790 http://dx.doi.org/10.1186/s43141-021-00214-2 |
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