Molecular noise filtering in the β-adrenergic signaling network by phospholamban pentamers

Phospholamban (PLN) is an important regulator of cardiac calcium handling due to its ability to inhibit the calcium ATPase SERCA. β-Adrenergic stimulation reverses SERCA inhibition via PLN phosphorylation and facilitates fast calcium reuptake. PLN also forms pentamers whose physiological significanc...

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Detalles Bibliográficos
Autores principales: Koch, Daniel, Alexandrovich, Alexander, Funk, Florian, Kho, Ay Lin, Schmitt, Joachim P., Gautel, Mathias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8333238/
https://www.ncbi.nlm.nih.gov/pubmed/34320358
http://dx.doi.org/10.1016/j.celrep.2021.109448

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