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Cortical representation of experimental periodontal pain: a functional magnetic resonance imaging study

The aim of this study was to investigate central pain representations during loading of the periodontium induced by orthodontic and occlusal stress. Nineteen healthy male volunteers (25.7 ± 2.8 years) were tested on two consecutive days: after phenotyping (questionnaires) and determination of warmth...

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Autores principales: Maurer, Angelika, Verma, Damian, Reddehase, Annika, Scheef, Lukas, Radbruch, Alexander, Attenberger, Ulrike, Jäger, Andreas, Boecker, Henning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8333250/
https://www.ncbi.nlm.nih.gov/pubmed/34344918
http://dx.doi.org/10.1038/s41598-021-94775-4
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author Maurer, Angelika
Verma, Damian
Reddehase, Annika
Scheef, Lukas
Radbruch, Alexander
Attenberger, Ulrike
Jäger, Andreas
Boecker, Henning
author_facet Maurer, Angelika
Verma, Damian
Reddehase, Annika
Scheef, Lukas
Radbruch, Alexander
Attenberger, Ulrike
Jäger, Andreas
Boecker, Henning
author_sort Maurer, Angelika
collection PubMed
description The aim of this study was to investigate central pain representations during loading of the periodontium induced by orthodontic and occlusal stress. Nineteen healthy male volunteers (25.7 ± 2.8 years) were tested on two consecutive days: after phenotyping (questionnaires) and determination of warmth (WPT) and heat (HPT) pain thresholds, functional magnetic resonance imaging was performed as event-related paradigm including 36 tooth clenchings of 3 s duration, alternating with rest periods varying between 20–30 s. The task was performed in absence (T1) and 24 h after placement of an elastic separator between the second bicuspid and the first molar on the right side of the lower jaw (T2). No significant changes in WPT and HPT were observed but pain ratings were significantly elevated at T2. Significantly elevated activation at T2, as compared to T1, was found in bilateral sensorimotor cortex, bilateral secondary sensory cortex, supplementary motor area, right rolandic operculum, and bilateral insula. Our data show for the first time in humans that periodontal stimulation, as tested by tooth clenching in the presence of an elastic separator, goes along with specific expressions of pain at behavioral and neuronal network levels. Findings supplement the existing neuroimaging literature on odontogenic pain.
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spelling pubmed-83332502021-08-04 Cortical representation of experimental periodontal pain: a functional magnetic resonance imaging study Maurer, Angelika Verma, Damian Reddehase, Annika Scheef, Lukas Radbruch, Alexander Attenberger, Ulrike Jäger, Andreas Boecker, Henning Sci Rep Article The aim of this study was to investigate central pain representations during loading of the periodontium induced by orthodontic and occlusal stress. Nineteen healthy male volunteers (25.7 ± 2.8 years) were tested on two consecutive days: after phenotyping (questionnaires) and determination of warmth (WPT) and heat (HPT) pain thresholds, functional magnetic resonance imaging was performed as event-related paradigm including 36 tooth clenchings of 3 s duration, alternating with rest periods varying between 20–30 s. The task was performed in absence (T1) and 24 h after placement of an elastic separator between the second bicuspid and the first molar on the right side of the lower jaw (T2). No significant changes in WPT and HPT were observed but pain ratings were significantly elevated at T2. Significantly elevated activation at T2, as compared to T1, was found in bilateral sensorimotor cortex, bilateral secondary sensory cortex, supplementary motor area, right rolandic operculum, and bilateral insula. Our data show for the first time in humans that periodontal stimulation, as tested by tooth clenching in the presence of an elastic separator, goes along with specific expressions of pain at behavioral and neuronal network levels. Findings supplement the existing neuroimaging literature on odontogenic pain. Nature Publishing Group UK 2021-08-03 /pmc/articles/PMC8333250/ /pubmed/34344918 http://dx.doi.org/10.1038/s41598-021-94775-4 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Maurer, Angelika
Verma, Damian
Reddehase, Annika
Scheef, Lukas
Radbruch, Alexander
Attenberger, Ulrike
Jäger, Andreas
Boecker, Henning
Cortical representation of experimental periodontal pain: a functional magnetic resonance imaging study
title Cortical representation of experimental periodontal pain: a functional magnetic resonance imaging study
title_full Cortical representation of experimental periodontal pain: a functional magnetic resonance imaging study
title_fullStr Cortical representation of experimental periodontal pain: a functional magnetic resonance imaging study
title_full_unstemmed Cortical representation of experimental periodontal pain: a functional magnetic resonance imaging study
title_short Cortical representation of experimental periodontal pain: a functional magnetic resonance imaging study
title_sort cortical representation of experimental periodontal pain: a functional magnetic resonance imaging study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8333250/
https://www.ncbi.nlm.nih.gov/pubmed/34344918
http://dx.doi.org/10.1038/s41598-021-94775-4
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