Cargando…

Impact of non-cystic fibrosis bronchiectasis on critically ill patients in Korea: a retrospective observational study

This study investigated the impact of bronchiectasis on patients admitted to the intensive care unit (ICU) at a hospital in Korea. Patients with bronchiectasis were diagnosed using results of chest computed tomography performed before ICU admission. The severity of bronchiectasis was based on the nu...

Descripción completa

Detalles Bibliográficos
Autores principales: Park, Youngmok, Yong, Seung Hyun, Leem, Ah Young, Kim, Song Yee, Lee, Sang Hoon, Chung, Kyungsoo, Kim, Eun Young, Jung, Ji Ye, Kang, Young Ae, Park, Moo Suk, Kim, Young Sam, Lee, Su Hwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8333349/
https://www.ncbi.nlm.nih.gov/pubmed/34345008
http://dx.doi.org/10.1038/s41598-021-95366-z
_version_ 1783733008677732352
author Park, Youngmok
Yong, Seung Hyun
Leem, Ah Young
Kim, Song Yee
Lee, Sang Hoon
Chung, Kyungsoo
Kim, Eun Young
Jung, Ji Ye
Kang, Young Ae
Park, Moo Suk
Kim, Young Sam
Lee, Su Hwan
author_facet Park, Youngmok
Yong, Seung Hyun
Leem, Ah Young
Kim, Song Yee
Lee, Sang Hoon
Chung, Kyungsoo
Kim, Eun Young
Jung, Ji Ye
Kang, Young Ae
Park, Moo Suk
Kim, Young Sam
Lee, Su Hwan
author_sort Park, Youngmok
collection PubMed
description This study investigated the impact of bronchiectasis on patients admitted to the intensive care unit (ICU) at a hospital in Korea. Patients with bronchiectasis were diagnosed using results of chest computed tomography performed before ICU admission. The severity of bronchiectasis was based on the number of affected lobes, and patients with ≥ 3 bronchiectatic lobes were classified into the severe bronchiectasis group. Overall, 823 patients were enrolled. The mean age was 66.0 ± 13.9 years, and 63.4% were men. Bronchiectasis and severe bronchiectasis were present in 148 (18.0%) and 108 (13.1%) patients, respectively. The increase in the number of bronchiectatic lobes was related to the rise in ICU mortality (P for trend = 0.012) and in-hospital mortality (P for trend = 0.004). Patients with severe bronchiectasis had higher odds for 28-day mortality [odds ratio (OR) 1.122, 95% confidence interval (CI) 1.024–1.230], ICU mortality (OR 1.119, 95% CI 1.023–1.223), and in-hospital mortality (OR 1.208, 95% CI 1.092–1.337). The severe bronchiectasis group showed lower overall survival (log-rank P < 0.001), and the adjusted hazard ratio was 1.535 (95% CI 1.178–2.001). Severe bronchiectasis had a negative impact on all-cause mortality during ICU and hospital stays, resulting in a lower survival rate.
format Online
Article
Text
id pubmed-8333349
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-83333492021-08-05 Impact of non-cystic fibrosis bronchiectasis on critically ill patients in Korea: a retrospective observational study Park, Youngmok Yong, Seung Hyun Leem, Ah Young Kim, Song Yee Lee, Sang Hoon Chung, Kyungsoo Kim, Eun Young Jung, Ji Ye Kang, Young Ae Park, Moo Suk Kim, Young Sam Lee, Su Hwan Sci Rep Article This study investigated the impact of bronchiectasis on patients admitted to the intensive care unit (ICU) at a hospital in Korea. Patients with bronchiectasis were diagnosed using results of chest computed tomography performed before ICU admission. The severity of bronchiectasis was based on the number of affected lobes, and patients with ≥ 3 bronchiectatic lobes were classified into the severe bronchiectasis group. Overall, 823 patients were enrolled. The mean age was 66.0 ± 13.9 years, and 63.4% were men. Bronchiectasis and severe bronchiectasis were present in 148 (18.0%) and 108 (13.1%) patients, respectively. The increase in the number of bronchiectatic lobes was related to the rise in ICU mortality (P for trend = 0.012) and in-hospital mortality (P for trend = 0.004). Patients with severe bronchiectasis had higher odds for 28-day mortality [odds ratio (OR) 1.122, 95% confidence interval (CI) 1.024–1.230], ICU mortality (OR 1.119, 95% CI 1.023–1.223), and in-hospital mortality (OR 1.208, 95% CI 1.092–1.337). The severe bronchiectasis group showed lower overall survival (log-rank P < 0.001), and the adjusted hazard ratio was 1.535 (95% CI 1.178–2.001). Severe bronchiectasis had a negative impact on all-cause mortality during ICU and hospital stays, resulting in a lower survival rate. Nature Publishing Group UK 2021-08-03 /pmc/articles/PMC8333349/ /pubmed/34345008 http://dx.doi.org/10.1038/s41598-021-95366-z Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Park, Youngmok
Yong, Seung Hyun
Leem, Ah Young
Kim, Song Yee
Lee, Sang Hoon
Chung, Kyungsoo
Kim, Eun Young
Jung, Ji Ye
Kang, Young Ae
Park, Moo Suk
Kim, Young Sam
Lee, Su Hwan
Impact of non-cystic fibrosis bronchiectasis on critically ill patients in Korea: a retrospective observational study
title Impact of non-cystic fibrosis bronchiectasis on critically ill patients in Korea: a retrospective observational study
title_full Impact of non-cystic fibrosis bronchiectasis on critically ill patients in Korea: a retrospective observational study
title_fullStr Impact of non-cystic fibrosis bronchiectasis on critically ill patients in Korea: a retrospective observational study
title_full_unstemmed Impact of non-cystic fibrosis bronchiectasis on critically ill patients in Korea: a retrospective observational study
title_short Impact of non-cystic fibrosis bronchiectasis on critically ill patients in Korea: a retrospective observational study
title_sort impact of non-cystic fibrosis bronchiectasis on critically ill patients in korea: a retrospective observational study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8333349/
https://www.ncbi.nlm.nih.gov/pubmed/34345008
http://dx.doi.org/10.1038/s41598-021-95366-z
work_keys_str_mv AT parkyoungmok impactofnoncysticfibrosisbronchiectasisoncriticallyillpatientsinkoreaaretrospectiveobservationalstudy
AT yongseunghyun impactofnoncysticfibrosisbronchiectasisoncriticallyillpatientsinkoreaaretrospectiveobservationalstudy
AT leemahyoung impactofnoncysticfibrosisbronchiectasisoncriticallyillpatientsinkoreaaretrospectiveobservationalstudy
AT kimsongyee impactofnoncysticfibrosisbronchiectasisoncriticallyillpatientsinkoreaaretrospectiveobservationalstudy
AT leesanghoon impactofnoncysticfibrosisbronchiectasisoncriticallyillpatientsinkoreaaretrospectiveobservationalstudy
AT chungkyungsoo impactofnoncysticfibrosisbronchiectasisoncriticallyillpatientsinkoreaaretrospectiveobservationalstudy
AT kimeunyoung impactofnoncysticfibrosisbronchiectasisoncriticallyillpatientsinkoreaaretrospectiveobservationalstudy
AT jungjiye impactofnoncysticfibrosisbronchiectasisoncriticallyillpatientsinkoreaaretrospectiveobservationalstudy
AT kangyoungae impactofnoncysticfibrosisbronchiectasisoncriticallyillpatientsinkoreaaretrospectiveobservationalstudy
AT parkmoosuk impactofnoncysticfibrosisbronchiectasisoncriticallyillpatientsinkoreaaretrospectiveobservationalstudy
AT kimyoungsam impactofnoncysticfibrosisbronchiectasisoncriticallyillpatientsinkoreaaretrospectiveobservationalstudy
AT leesuhwan impactofnoncysticfibrosisbronchiectasisoncriticallyillpatientsinkoreaaretrospectiveobservationalstudy