The ZEB2‐dependent EMT transcriptional programme drives therapy resistance by activating nucleotide excision repair genes ERCC1 and ERCC4 in colorectal cancer

Resistance to adjuvant chemotherapy is a major clinical problem in the treatment of colorectal cancer (CRC). The aim of this study was to elucidate the role of an epithelial to mesenchymal transition (EMT)‐inducing protein, ZEB2, in chemoresistance of CRC, and to uncover the underlying mechanism. We...

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Detalles Bibliográficos
Autores principales: Sreekumar, Rahul, Al‐Saihati, Hajir, Emaduddin, Muhammad, Moutasim, Karwan, Mellone, Massimiliano, Patel, Ashish, Kilic, Seval, Cetin, Metin, Erdemir, Sule, Navio, Marta Salgado, Lopez, Maria Antonette, Curtis, Nathan, Yagci, Tamer, Primrose, John N., Price, Brendan D., Berx, Geert, Thomas, Gareth J., Tulchinsky, Eugene, Mirnezami, Alex, Sayan, A. Emre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8333771/
https://www.ncbi.nlm.nih.gov/pubmed/33931939
http://dx.doi.org/10.1002/1878-0261.12965

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