Epigenetic regulator BMI1 promotes alveolar rhabdomyosarcoma proliferation and constitutes a novel therapeutic target

Rhabdomyosarcoma (RMS) is an aggressive pediatric soft tissue sarcoma. There are two main subtypes of RMS, alveolar rhabdomyosarcoma (ARMS) and embryonal rhabdomyosarcoma. ARMS typically encompasses fusion‐positive rhabdomyosarcoma, which expresses either PAX3‐FOXO1 or PAX7‐FOXO1 fusion proteins. Th...

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Detalles Bibliográficos
Autores principales: Shields, Cara E., Potlapalli, Sindhu, Cuya‐Smith, Selma M., Chappell, Sarah K., Chen, Dongdong, Martinez, Daniel, Pogoriler, Jennifer, Rathi, Komal S., Patel, Shiv A., Oristian, Kristianne M., Linardic, Corinne M., Maris, John M., Haynes, Karmella A., Schnepp, Robert W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8333775/
https://www.ncbi.nlm.nih.gov/pubmed/33523558
http://dx.doi.org/10.1002/1878-0261.12914

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