The Biogenesis, Biological Functions, and Applications of Macrophage-Derived Exosomes

Macrophage-derived exosomes have been implicated on the modulation of inflammatory processes. Recent studies have shown that macrophage-derived exosomes contribute to the progression of many diseases such as cancer, atherosclerosis, diabetes and heart failure. This review describes the biogenesis of...

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Autores principales: Shan, Xiaoxiao, Zhang, Caiyun, Mai, Chutian, Hu, Xuerui, Cheng, Nuo, Chen, Weidong, Peng, Daiyin, Wang, Lei, Ji, Zhaojie, Xie, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8333870/
https://www.ncbi.nlm.nih.gov/pubmed/34368234
http://dx.doi.org/10.3389/fmolb.2021.715461
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author Shan, Xiaoxiao
Zhang, Caiyun
Mai, Chutian
Hu, Xuerui
Cheng, Nuo
Chen, Weidong
Peng, Daiyin
Wang, Lei
Ji, Zhaojie
Xie, Ying
author_facet Shan, Xiaoxiao
Zhang, Caiyun
Mai, Chutian
Hu, Xuerui
Cheng, Nuo
Chen, Weidong
Peng, Daiyin
Wang, Lei
Ji, Zhaojie
Xie, Ying
author_sort Shan, Xiaoxiao
collection PubMed
description Macrophage-derived exosomes have been implicated on the modulation of inflammatory processes. Recent studies have shown that macrophage-derived exosomes contribute to the progression of many diseases such as cancer, atherosclerosis, diabetes and heart failure. This review describes the biogenesis of macrophage-derived exosomes and their biological functions in different diseases. In addition, the challenges facing the use of macrophage-derived exosomes as delivery tools for drugs, genes, and proteins in clinical applications are described. The application of macrophage-derived exosomes in the diagnosis and treatment of diseases is also discussed.
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spelling pubmed-83338702021-08-05 The Biogenesis, Biological Functions, and Applications of Macrophage-Derived Exosomes Shan, Xiaoxiao Zhang, Caiyun Mai, Chutian Hu, Xuerui Cheng, Nuo Chen, Weidong Peng, Daiyin Wang, Lei Ji, Zhaojie Xie, Ying Front Mol Biosci Molecular Biosciences Macrophage-derived exosomes have been implicated on the modulation of inflammatory processes. Recent studies have shown that macrophage-derived exosomes contribute to the progression of many diseases such as cancer, atherosclerosis, diabetes and heart failure. This review describes the biogenesis of macrophage-derived exosomes and their biological functions in different diseases. In addition, the challenges facing the use of macrophage-derived exosomes as delivery tools for drugs, genes, and proteins in clinical applications are described. The application of macrophage-derived exosomes in the diagnosis and treatment of diseases is also discussed. Frontiers Media S.A. 2021-07-21 /pmc/articles/PMC8333870/ /pubmed/34368234 http://dx.doi.org/10.3389/fmolb.2021.715461 Text en Copyright © 2021 Shan, Zhang, Mai, Hu, Cheng, Chen, Peng, Wang, Ji and Xie. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Biosciences
Shan, Xiaoxiao
Zhang, Caiyun
Mai, Chutian
Hu, Xuerui
Cheng, Nuo
Chen, Weidong
Peng, Daiyin
Wang, Lei
Ji, Zhaojie
Xie, Ying
The Biogenesis, Biological Functions, and Applications of Macrophage-Derived Exosomes
title The Biogenesis, Biological Functions, and Applications of Macrophage-Derived Exosomes
title_full The Biogenesis, Biological Functions, and Applications of Macrophage-Derived Exosomes
title_fullStr The Biogenesis, Biological Functions, and Applications of Macrophage-Derived Exosomes
title_full_unstemmed The Biogenesis, Biological Functions, and Applications of Macrophage-Derived Exosomes
title_short The Biogenesis, Biological Functions, and Applications of Macrophage-Derived Exosomes
title_sort biogenesis, biological functions, and applications of macrophage-derived exosomes
topic Molecular Biosciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8333870/
https://www.ncbi.nlm.nih.gov/pubmed/34368234
http://dx.doi.org/10.3389/fmolb.2021.715461
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