Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox Gene Temporal Collinear Activation for Body Axial Patterning in Mice

Body axial patterning develops via a rostral-to-caudal sequence and relies on the temporal colinear activation of Hox genes. However, the underlying mechanism of Hox gene temporal colinear activation remains largely elusive. Here, with small-molecule inhibitors and conditional gene knockout mice, we...

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Detalles Bibliográficos
Autores principales: Zhang, Feng, Zhao, Xiong, Jiang, Runmin, Wang, Yuying, Wang, Xinli, Gu, Yu, Xu, Longyong, Ye, Jing, Chen, Charlie Degui, Guo, Shuangping, Zhang, Dawei, Zhao, Daqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8333871/
https://www.ncbi.nlm.nih.gov/pubmed/34368113
http://dx.doi.org/10.3389/fcell.2021.642931

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