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Exploring Phytochemicals for Combating Antibiotic Resistance in Microbial Pathogens

Antibiotic resistance or microbial drug resistance is emerging as a serious threat to human healthcare globally, and the multidrug-resistant (MDR) strains are imposing major hurdles to the progression of drug discovery programs. Newer antibiotic-resistance mechanisms in microbes contribute to the in...

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Autores principales: Khare, Tushar, Anand, Uttpal, Dey, Abhijit, Assaraf, Yehuda G., Chen, Zhe-Sheng, Liu, Zhijun, Kumar, Vinay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8334005/
https://www.ncbi.nlm.nih.gov/pubmed/34366872
http://dx.doi.org/10.3389/fphar.2021.720726
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author Khare, Tushar
Anand, Uttpal
Dey, Abhijit
Assaraf, Yehuda G.
Chen, Zhe-Sheng
Liu, Zhijun
Kumar, Vinay
author_facet Khare, Tushar
Anand, Uttpal
Dey, Abhijit
Assaraf, Yehuda G.
Chen, Zhe-Sheng
Liu, Zhijun
Kumar, Vinay
author_sort Khare, Tushar
collection PubMed
description Antibiotic resistance or microbial drug resistance is emerging as a serious threat to human healthcare globally, and the multidrug-resistant (MDR) strains are imposing major hurdles to the progression of drug discovery programs. Newer antibiotic-resistance mechanisms in microbes contribute to the inefficacy of the existing drugs along with the prolonged illness and escalating expenditures. The injudicious usage of the conventional and commonly available antibiotics in human health, hygiene, veterinary and agricultural practices is proving to be a major driver for evolution, persistence and spread of antibiotic-resistance at a frightening rate. The drying pipeline of new and potent antibiotics is adding to the severity. Therefore, novel and effective new drugs and innovative therapies to treat MDR infections are urgently needed. Apart from the different natural and synthetic drugs being tested, plant secondary metabolites or phytochemicals are proving efficient in combating the drug-resistant strains. Various phytochemicals from classes including alkaloids, phenols, coumarins, terpenes have been successfully demonstrated their inhibitory potential against the drug-resistant pathogens. Several phytochemicals have proved effective against the molecular determinants responsible for attaining the drug resistance in pathogens like membrane proteins, biofilms, efflux pumps and bacterial cell communications. However, translational success rate needs to be improved, but the trends are encouraging. This review highlights current knowledge and developments associated challenges and future prospects for the successful application of phytochemicals in combating antibiotic resistance and the resistant microbial pathogens.
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spelling pubmed-83340052021-08-05 Exploring Phytochemicals for Combating Antibiotic Resistance in Microbial Pathogens Khare, Tushar Anand, Uttpal Dey, Abhijit Assaraf, Yehuda G. Chen, Zhe-Sheng Liu, Zhijun Kumar, Vinay Front Pharmacol Pharmacology Antibiotic resistance or microbial drug resistance is emerging as a serious threat to human healthcare globally, and the multidrug-resistant (MDR) strains are imposing major hurdles to the progression of drug discovery programs. Newer antibiotic-resistance mechanisms in microbes contribute to the inefficacy of the existing drugs along with the prolonged illness and escalating expenditures. The injudicious usage of the conventional and commonly available antibiotics in human health, hygiene, veterinary and agricultural practices is proving to be a major driver for evolution, persistence and spread of antibiotic-resistance at a frightening rate. The drying pipeline of new and potent antibiotics is adding to the severity. Therefore, novel and effective new drugs and innovative therapies to treat MDR infections are urgently needed. Apart from the different natural and synthetic drugs being tested, plant secondary metabolites or phytochemicals are proving efficient in combating the drug-resistant strains. Various phytochemicals from classes including alkaloids, phenols, coumarins, terpenes have been successfully demonstrated their inhibitory potential against the drug-resistant pathogens. Several phytochemicals have proved effective against the molecular determinants responsible for attaining the drug resistance in pathogens like membrane proteins, biofilms, efflux pumps and bacterial cell communications. However, translational success rate needs to be improved, but the trends are encouraging. This review highlights current knowledge and developments associated challenges and future prospects for the successful application of phytochemicals in combating antibiotic resistance and the resistant microbial pathogens. Frontiers Media S.A. 2021-07-21 /pmc/articles/PMC8334005/ /pubmed/34366872 http://dx.doi.org/10.3389/fphar.2021.720726 Text en Copyright © 2021 Khare, Anand, Dey, Assaraf, Chen, Liu and Kumar. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Khare, Tushar
Anand, Uttpal
Dey, Abhijit
Assaraf, Yehuda G.
Chen, Zhe-Sheng
Liu, Zhijun
Kumar, Vinay
Exploring Phytochemicals for Combating Antibiotic Resistance in Microbial Pathogens
title Exploring Phytochemicals for Combating Antibiotic Resistance in Microbial Pathogens
title_full Exploring Phytochemicals for Combating Antibiotic Resistance in Microbial Pathogens
title_fullStr Exploring Phytochemicals for Combating Antibiotic Resistance in Microbial Pathogens
title_full_unstemmed Exploring Phytochemicals for Combating Antibiotic Resistance in Microbial Pathogens
title_short Exploring Phytochemicals for Combating Antibiotic Resistance in Microbial Pathogens
title_sort exploring phytochemicals for combating antibiotic resistance in microbial pathogens
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8334005/
https://www.ncbi.nlm.nih.gov/pubmed/34366872
http://dx.doi.org/10.3389/fphar.2021.720726
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