Case Report: Capillary Leak Syndrome With Kidney Transplant Failure Following Autologous Mesenchymal Stem Cell Therapy

Mesenchymal stem cells (MSCs) have attracted great interest in the field of kidney transplantation due to their immunomodulatory and reparative properties. In registered clinical trials, MSCs have been used before, at the time of, or early after transplantation and have been reported to be well-tole...

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Autores principales: Večerić-Haler, Željka, Kojc, Nika, Sever, Matjaž, Zver, Samo, Švajger, Urban, Poženel, Primož, Hartman, Katrina, Urdih, Tereza, Mlinšek, Gregor, Oblak, Manca, Aleš Rigler, Andreja, Ihan, Alojz, Buturović Ponikvar, Jadranka, Halloran, Philip P., Arnol, Miha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8334176/
https://www.ncbi.nlm.nih.gov/pubmed/34368198
http://dx.doi.org/10.3389/fmed.2021.708744
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author Večerić-Haler, Željka
Kojc, Nika
Sever, Matjaž
Zver, Samo
Švajger, Urban
Poženel, Primož
Hartman, Katrina
Urdih, Tereza
Mlinšek, Gregor
Oblak, Manca
Aleš Rigler, Andreja
Ihan, Alojz
Buturović Ponikvar, Jadranka
Halloran, Philip P.
Arnol, Miha
author_facet Večerić-Haler, Željka
Kojc, Nika
Sever, Matjaž
Zver, Samo
Švajger, Urban
Poženel, Primož
Hartman, Katrina
Urdih, Tereza
Mlinšek, Gregor
Oblak, Manca
Aleš Rigler, Andreja
Ihan, Alojz
Buturović Ponikvar, Jadranka
Halloran, Philip P.
Arnol, Miha
author_sort Večerić-Haler, Željka
collection PubMed
description Mesenchymal stem cells (MSCs) have attracted great interest in the field of kidney transplantation due to their immunomodulatory and reparative properties. In registered clinical trials, MSCs have been used before, at the time of, or early after transplantation and have been reported to be well-tolerated with no serious safety concerns. No results are available on the use of MSCs in the late post-transplant period. Here, we present a case report of a severe systemic complication mimicking capillary leak syndrome with ultimate kidney transplant failure after autologous transplantation of MSCs used as rescue treatment of late antibody-mediated kidney allograft rejection.
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spelling pubmed-83341762021-08-05 Case Report: Capillary Leak Syndrome With Kidney Transplant Failure Following Autologous Mesenchymal Stem Cell Therapy Večerić-Haler, Željka Kojc, Nika Sever, Matjaž Zver, Samo Švajger, Urban Poženel, Primož Hartman, Katrina Urdih, Tereza Mlinšek, Gregor Oblak, Manca Aleš Rigler, Andreja Ihan, Alojz Buturović Ponikvar, Jadranka Halloran, Philip P. Arnol, Miha Front Med (Lausanne) Medicine Mesenchymal stem cells (MSCs) have attracted great interest in the field of kidney transplantation due to their immunomodulatory and reparative properties. In registered clinical trials, MSCs have been used before, at the time of, or early after transplantation and have been reported to be well-tolerated with no serious safety concerns. No results are available on the use of MSCs in the late post-transplant period. Here, we present a case report of a severe systemic complication mimicking capillary leak syndrome with ultimate kidney transplant failure after autologous transplantation of MSCs used as rescue treatment of late antibody-mediated kidney allograft rejection. Frontiers Media S.A. 2021-07-21 /pmc/articles/PMC8334176/ /pubmed/34368198 http://dx.doi.org/10.3389/fmed.2021.708744 Text en Copyright © 2021 Večerić-Haler, Kojc, Sever, Zver, Švajger, Poženel, Hartman, Urdih, Mlinšek, Oblak, Aleš Rigler, Ihan, Buturović Ponikvar, Halloran and Arnol. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Večerić-Haler, Željka
Kojc, Nika
Sever, Matjaž
Zver, Samo
Švajger, Urban
Poženel, Primož
Hartman, Katrina
Urdih, Tereza
Mlinšek, Gregor
Oblak, Manca
Aleš Rigler, Andreja
Ihan, Alojz
Buturović Ponikvar, Jadranka
Halloran, Philip P.
Arnol, Miha
Case Report: Capillary Leak Syndrome With Kidney Transplant Failure Following Autologous Mesenchymal Stem Cell Therapy
title Case Report: Capillary Leak Syndrome With Kidney Transplant Failure Following Autologous Mesenchymal Stem Cell Therapy
title_full Case Report: Capillary Leak Syndrome With Kidney Transplant Failure Following Autologous Mesenchymal Stem Cell Therapy
title_fullStr Case Report: Capillary Leak Syndrome With Kidney Transplant Failure Following Autologous Mesenchymal Stem Cell Therapy
title_full_unstemmed Case Report: Capillary Leak Syndrome With Kidney Transplant Failure Following Autologous Mesenchymal Stem Cell Therapy
title_short Case Report: Capillary Leak Syndrome With Kidney Transplant Failure Following Autologous Mesenchymal Stem Cell Therapy
title_sort case report: capillary leak syndrome with kidney transplant failure following autologous mesenchymal stem cell therapy
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8334176/
https://www.ncbi.nlm.nih.gov/pubmed/34368198
http://dx.doi.org/10.3389/fmed.2021.708744
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