Trop-2 induces ADAM10-mediated cleavage of E-cadherin and drives EMT-less metastasis in colon cancer

We recently reported that activation of Trop-2 through its cleavage at R87-T88 by ADAM10 underlies Trop-2–driven progression of colon cancer. However, the mechanism of action and pathological impact of Trop-2 in metastatic diffusion remain unexplored. Through searches for molecular determinants of c...

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Detalles Bibliográficos
Autores principales: Guerra, Emanuela, Trerotola, Marco, Relli, Valeria, Lattanzio, Rossano, Tripaldi, Romina, Vacca, Giovanna, Ceci, Martina, Boujnah, Khouloud, Garbo, Valeria, Moschella, Antonino, Zappacosta, Romina, Simeone, Pasquale, de Lange, Robert, Weidle, Ulrich H., Rotelli, Maria Teresa, Picciariello, Arcangelo, Depalo, Raffaella, Querzoli, Patrizia, Pedriali, Massimo, Bianchini, Enzo, Angelucci, Domenico, Pizzicannella, Giuseppe, Di Loreto, Carla, Piantelli, Mauro, Antolini, Laura, Sun, Xiao-Feng, Altomare, Donato F., Alberti, Saverio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8334386/
https://www.ncbi.nlm.nih.gov/pubmed/34320447
http://dx.doi.org/10.1016/j.neo.2021.07.002

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