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Central 5-HTR2C in the Control of Metabolic Homeostasis

The 5-hydroxytryptamine 2C receptor (5-HTR2C) is a class G protein-coupled receptor (GPCR) enriched in the hypothalamus and the brain stem, where it has been shown to regulate energy homeostasis, including feeding and glucose metabolism. Accordingly, 5-HTR2C has been the target of several anti-obesi...

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Autores principales: Yao, Ting, He, Jiehui, Cui, Zhicheng, Wang, Ruwen, Bao, Kaixuan, Huang, Yiru, Wang, Ru, Liu, Tiemin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8334728/
https://www.ncbi.nlm.nih.gov/pubmed/34367066
http://dx.doi.org/10.3389/fendo.2021.694204
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author Yao, Ting
He, Jiehui
Cui, Zhicheng
Wang, Ruwen
Bao, Kaixuan
Huang, Yiru
Wang, Ru
Liu, Tiemin
author_facet Yao, Ting
He, Jiehui
Cui, Zhicheng
Wang, Ruwen
Bao, Kaixuan
Huang, Yiru
Wang, Ru
Liu, Tiemin
author_sort Yao, Ting
collection PubMed
description The 5-hydroxytryptamine 2C receptor (5-HTR2C) is a class G protein-coupled receptor (GPCR) enriched in the hypothalamus and the brain stem, where it has been shown to regulate energy homeostasis, including feeding and glucose metabolism. Accordingly, 5-HTR2C has been the target of several anti-obesity drugs, though the associated side effects greatly curbed their clinical applications. Dissecting the specific neural circuits of 5-HTR2C-expressing neurons and the detailed molecular pathways of 5-HTR2C signaling in metabolic regulation will help to develop better therapeutic strategies towards metabolic disorders. In this review, we introduced the regulatory role of 5-HTR2C in feeding behavior and glucose metabolism, with particular focus on the molecular pathways, neural network, and its interaction with other metabolic hormones, such as leptin, ghrelin, insulin, and estrogens. Moreover, the latest progress in the clinical research on 5-HTR2C agonists was also discussed.
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spelling pubmed-83347282021-08-05 Central 5-HTR2C in the Control of Metabolic Homeostasis Yao, Ting He, Jiehui Cui, Zhicheng Wang, Ruwen Bao, Kaixuan Huang, Yiru Wang, Ru Liu, Tiemin Front Endocrinol (Lausanne) Endocrinology The 5-hydroxytryptamine 2C receptor (5-HTR2C) is a class G protein-coupled receptor (GPCR) enriched in the hypothalamus and the brain stem, where it has been shown to regulate energy homeostasis, including feeding and glucose metabolism. Accordingly, 5-HTR2C has been the target of several anti-obesity drugs, though the associated side effects greatly curbed their clinical applications. Dissecting the specific neural circuits of 5-HTR2C-expressing neurons and the detailed molecular pathways of 5-HTR2C signaling in metabolic regulation will help to develop better therapeutic strategies towards metabolic disorders. In this review, we introduced the regulatory role of 5-HTR2C in feeding behavior and glucose metabolism, with particular focus on the molecular pathways, neural network, and its interaction with other metabolic hormones, such as leptin, ghrelin, insulin, and estrogens. Moreover, the latest progress in the clinical research on 5-HTR2C agonists was also discussed. Frontiers Media S.A. 2021-07-21 /pmc/articles/PMC8334728/ /pubmed/34367066 http://dx.doi.org/10.3389/fendo.2021.694204 Text en Copyright © 2021 Yao, He, Cui, Wang, Bao, Huang, Wang and Liu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Yao, Ting
He, Jiehui
Cui, Zhicheng
Wang, Ruwen
Bao, Kaixuan
Huang, Yiru
Wang, Ru
Liu, Tiemin
Central 5-HTR2C in the Control of Metabolic Homeostasis
title Central 5-HTR2C in the Control of Metabolic Homeostasis
title_full Central 5-HTR2C in the Control of Metabolic Homeostasis
title_fullStr Central 5-HTR2C in the Control of Metabolic Homeostasis
title_full_unstemmed Central 5-HTR2C in the Control of Metabolic Homeostasis
title_short Central 5-HTR2C in the Control of Metabolic Homeostasis
title_sort central 5-htr2c in the control of metabolic homeostasis
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8334728/
https://www.ncbi.nlm.nih.gov/pubmed/34367066
http://dx.doi.org/10.3389/fendo.2021.694204
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