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Targeting Aging: Lessons Learned From Immunometabolism and Cellular Senescence

It is well known that aging is associated with dysregulated metabolism. This is seen both in terms of systemic metabolism, as well as at the cellular level with clear mitochondrial dysfunction. More recently, the importance of cellular metabolism in immune cells, or immunometabolism, has been highli...

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Autores principales: Martin, Dominique E., Torrance, Blake L., Haynes, Laura, Bartley, Jenna M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8334863/
https://www.ncbi.nlm.nih.gov/pubmed/34367184
http://dx.doi.org/10.3389/fimmu.2021.714742
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author Martin, Dominique E.
Torrance, Blake L.
Haynes, Laura
Bartley, Jenna M.
author_facet Martin, Dominique E.
Torrance, Blake L.
Haynes, Laura
Bartley, Jenna M.
author_sort Martin, Dominique E.
collection PubMed
description It is well known that aging is associated with dysregulated metabolism. This is seen both in terms of systemic metabolism, as well as at the cellular level with clear mitochondrial dysfunction. More recently, the importance of cellular metabolism in immune cells, or immunometabolism, has been highlighted as a major modifier of immune cell function. Indeed, T cell activation, differentiation, and effector function partly depend on alterations in metabolic pathways with different cell types and functionality favoring either glycolysis or oxidative phosphorylation. While immune system dysfunction with aging is well described, what remains less elucidated is how the integral networks that control immune cell metabolism are specifically affected by age. In recent years, this significant gap has been identified and work has begun to investigate the various ways immunometabolism could be impacted by both chronological age and age-associated symptoms, such as the systemic accumulation of senescent cells. Here, in this mini-review, we will examine immunometabolism with a focus on T cells, aging, and interventions, such as mTOR modulators and senolytics. This review also covers a timely perspective on how immunometabolism may be an ideal target for immunomodulation with aging.
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spelling pubmed-83348632021-08-05 Targeting Aging: Lessons Learned From Immunometabolism and Cellular Senescence Martin, Dominique E. Torrance, Blake L. Haynes, Laura Bartley, Jenna M. Front Immunol Immunology It is well known that aging is associated with dysregulated metabolism. This is seen both in terms of systemic metabolism, as well as at the cellular level with clear mitochondrial dysfunction. More recently, the importance of cellular metabolism in immune cells, or immunometabolism, has been highlighted as a major modifier of immune cell function. Indeed, T cell activation, differentiation, and effector function partly depend on alterations in metabolic pathways with different cell types and functionality favoring either glycolysis or oxidative phosphorylation. While immune system dysfunction with aging is well described, what remains less elucidated is how the integral networks that control immune cell metabolism are specifically affected by age. In recent years, this significant gap has been identified and work has begun to investigate the various ways immunometabolism could be impacted by both chronological age and age-associated symptoms, such as the systemic accumulation of senescent cells. Here, in this mini-review, we will examine immunometabolism with a focus on T cells, aging, and interventions, such as mTOR modulators and senolytics. This review also covers a timely perspective on how immunometabolism may be an ideal target for immunomodulation with aging. Frontiers Media S.A. 2021-07-21 /pmc/articles/PMC8334863/ /pubmed/34367184 http://dx.doi.org/10.3389/fimmu.2021.714742 Text en Copyright © 2021 Martin, Torrance, Haynes and Bartley https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Martin, Dominique E.
Torrance, Blake L.
Haynes, Laura
Bartley, Jenna M.
Targeting Aging: Lessons Learned From Immunometabolism and Cellular Senescence
title Targeting Aging: Lessons Learned From Immunometabolism and Cellular Senescence
title_full Targeting Aging: Lessons Learned From Immunometabolism and Cellular Senescence
title_fullStr Targeting Aging: Lessons Learned From Immunometabolism and Cellular Senescence
title_full_unstemmed Targeting Aging: Lessons Learned From Immunometabolism and Cellular Senescence
title_short Targeting Aging: Lessons Learned From Immunometabolism and Cellular Senescence
title_sort targeting aging: lessons learned from immunometabolism and cellular senescence
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8334863/
https://www.ncbi.nlm.nih.gov/pubmed/34367184
http://dx.doi.org/10.3389/fimmu.2021.714742
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