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The Genetic Changes of Hepatoblastoma

Hepatoblastoma is the most common malignant liver cancer in childhood. The etiology of hepatoblastoma remains obscure. Hepatoblastoma is closely related to genetic syndromes, hinting that hepatoblastoma is a genetic predisposition disease. However, no precise exposures or genetic events are reported...

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Autores principales: Chen, Huitong, Guan, Qian, Guo, Huiqin, Miao, Lei, Zhuo, Zhenjian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8335155/
https://www.ncbi.nlm.nih.gov/pubmed/34367972
http://dx.doi.org/10.3389/fonc.2021.690641
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author Chen, Huitong
Guan, Qian
Guo, Huiqin
Miao, Lei
Zhuo, Zhenjian
author_facet Chen, Huitong
Guan, Qian
Guo, Huiqin
Miao, Lei
Zhuo, Zhenjian
author_sort Chen, Huitong
collection PubMed
description Hepatoblastoma is the most common malignant liver cancer in childhood. The etiology of hepatoblastoma remains obscure. Hepatoblastoma is closely related to genetic syndromes, hinting that hepatoblastoma is a genetic predisposition disease. However, no precise exposures or genetic events are reported to hepatoblastoma occurrence. During the past decade, significant advances have been made in the understanding of etiology leading to hepatoblastoma, and several important genetic events that appear to be important for the development and progression of this tumor have been identified. Advances in our understanding of the genetic changes that underlie hepatoblastoma may translate into better patient outcomes. Single nucleotide polymorphisms (SNPs) have been generally applied in the research of etiology’s exploration, disease treatment, and prognosis assessment. Here, we reviewed and discussed the molecular epidemiology, especially SNPs progresses in hepatoblastoma, to provide references for future studies and promote the study of hepatoblastoma’s etiology.
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spelling pubmed-83351552021-08-05 The Genetic Changes of Hepatoblastoma Chen, Huitong Guan, Qian Guo, Huiqin Miao, Lei Zhuo, Zhenjian Front Oncol Oncology Hepatoblastoma is the most common malignant liver cancer in childhood. The etiology of hepatoblastoma remains obscure. Hepatoblastoma is closely related to genetic syndromes, hinting that hepatoblastoma is a genetic predisposition disease. However, no precise exposures or genetic events are reported to hepatoblastoma occurrence. During the past decade, significant advances have been made in the understanding of etiology leading to hepatoblastoma, and several important genetic events that appear to be important for the development and progression of this tumor have been identified. Advances in our understanding of the genetic changes that underlie hepatoblastoma may translate into better patient outcomes. Single nucleotide polymorphisms (SNPs) have been generally applied in the research of etiology’s exploration, disease treatment, and prognosis assessment. Here, we reviewed and discussed the molecular epidemiology, especially SNPs progresses in hepatoblastoma, to provide references for future studies and promote the study of hepatoblastoma’s etiology. Frontiers Media S.A. 2021-07-21 /pmc/articles/PMC8335155/ /pubmed/34367972 http://dx.doi.org/10.3389/fonc.2021.690641 Text en Copyright © 2021 Chen, Guan, Guo, Miao and Zhuo https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Chen, Huitong
Guan, Qian
Guo, Huiqin
Miao, Lei
Zhuo, Zhenjian
The Genetic Changes of Hepatoblastoma
title The Genetic Changes of Hepatoblastoma
title_full The Genetic Changes of Hepatoblastoma
title_fullStr The Genetic Changes of Hepatoblastoma
title_full_unstemmed The Genetic Changes of Hepatoblastoma
title_short The Genetic Changes of Hepatoblastoma
title_sort genetic changes of hepatoblastoma
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8335155/
https://www.ncbi.nlm.nih.gov/pubmed/34367972
http://dx.doi.org/10.3389/fonc.2021.690641
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