The Impact of lncRNAs and miRNAs on Apoptosis in Lung Cancer

Apoptosis is a coordinated cellular process that occurs in several physiological situations. Dysregulation of apoptosis has been documented in numerous pathological situations, particularly cancer. Non-coding RNAs regulate apoptosis via different mechanisms. Lung cancer is among neoplastic condition...

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Autores principales: Ghafouri-Fard, Soudeh, Aghabalazade, Amin, Shoorei, Hamed, Majidpoor, Jamal, Taheri, Mohammad, Mokhtari, Majid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8335161/
https://www.ncbi.nlm.nih.gov/pubmed/34367998
http://dx.doi.org/10.3389/fonc.2021.714795
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author Ghafouri-Fard, Soudeh
Aghabalazade, Amin
Shoorei, Hamed
Majidpoor, Jamal
Taheri, Mohammad
Mokhtari, Majid
author_facet Ghafouri-Fard, Soudeh
Aghabalazade, Amin
Shoorei, Hamed
Majidpoor, Jamal
Taheri, Mohammad
Mokhtari, Majid
author_sort Ghafouri-Fard, Soudeh
collection PubMed
description Apoptosis is a coordinated cellular process that occurs in several physiological situations. Dysregulation of apoptosis has been documented in numerous pathological situations, particularly cancer. Non-coding RNAs regulate apoptosis via different mechanisms. Lung cancer is among neoplastic conditions in which the role of non-coding RNAs in the regulation of apoptosis has been investigated. Non-coding RNAs that regulate apoptosis in lung cancer have functional interactions with PI3K/Akt, PTEN, GSK-3β, NF-κB, Bcl-2, Bax, p53, mTOR and other important cancer-related pathways. Globally, over-expression of apoptosis-blocking non-coding RNAs has been associated with poor prognosis of patients, while apoptosis-promoting ones have the opposite effect. In the current paper, we describe the impact of lncRNAs and miRNAs on cell apoptosis in lung cancer.
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spelling pubmed-83351612021-08-05 The Impact of lncRNAs and miRNAs on Apoptosis in Lung Cancer Ghafouri-Fard, Soudeh Aghabalazade, Amin Shoorei, Hamed Majidpoor, Jamal Taheri, Mohammad Mokhtari, Majid Front Oncol Oncology Apoptosis is a coordinated cellular process that occurs in several physiological situations. Dysregulation of apoptosis has been documented in numerous pathological situations, particularly cancer. Non-coding RNAs regulate apoptosis via different mechanisms. Lung cancer is among neoplastic conditions in which the role of non-coding RNAs in the regulation of apoptosis has been investigated. Non-coding RNAs that regulate apoptosis in lung cancer have functional interactions with PI3K/Akt, PTEN, GSK-3β, NF-κB, Bcl-2, Bax, p53, mTOR and other important cancer-related pathways. Globally, over-expression of apoptosis-blocking non-coding RNAs has been associated with poor prognosis of patients, while apoptosis-promoting ones have the opposite effect. In the current paper, we describe the impact of lncRNAs and miRNAs on cell apoptosis in lung cancer. Frontiers Media S.A. 2021-07-21 /pmc/articles/PMC8335161/ /pubmed/34367998 http://dx.doi.org/10.3389/fonc.2021.714795 Text en Copyright © 2021 Ghafouri-Fard, Aghabalazade, Shoorei, Majidpoor, Taheri and Mokhtari https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Ghafouri-Fard, Soudeh
Aghabalazade, Amin
Shoorei, Hamed
Majidpoor, Jamal
Taheri, Mohammad
Mokhtari, Majid
The Impact of lncRNAs and miRNAs on Apoptosis in Lung Cancer
title The Impact of lncRNAs and miRNAs on Apoptosis in Lung Cancer
title_full The Impact of lncRNAs and miRNAs on Apoptosis in Lung Cancer
title_fullStr The Impact of lncRNAs and miRNAs on Apoptosis in Lung Cancer
title_full_unstemmed The Impact of lncRNAs and miRNAs on Apoptosis in Lung Cancer
title_short The Impact of lncRNAs and miRNAs on Apoptosis in Lung Cancer
title_sort impact of lncrnas and mirnas on apoptosis in lung cancer
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8335161/
https://www.ncbi.nlm.nih.gov/pubmed/34367998
http://dx.doi.org/10.3389/fonc.2021.714795
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