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Sex Differences in Inflammation During Venous Remodeling of Arteriovenous Fistulae

Vascular disorders frequently have differing clinical presentations among women and men. Sex differences exist in vascular access for hemodialysis; women have reduced rates of arteriovenous fistula (AVF) maturation as well as fistula utilization compared with men. Inflammation is increasingly implic...

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Autores principales: Chan, Shin Mei, Weininger, Gabe, Langford, John, Jane-Wit, Daniel, Dardik, Alan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8335484/
https://www.ncbi.nlm.nih.gov/pubmed/34368264
http://dx.doi.org/10.3389/fcvm.2021.715114
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author Chan, Shin Mei
Weininger, Gabe
Langford, John
Jane-Wit, Daniel
Dardik, Alan
author_facet Chan, Shin Mei
Weininger, Gabe
Langford, John
Jane-Wit, Daniel
Dardik, Alan
author_sort Chan, Shin Mei
collection PubMed
description Vascular disorders frequently have differing clinical presentations among women and men. Sex differences exist in vascular access for hemodialysis; women have reduced rates of arteriovenous fistula (AVF) maturation as well as fistula utilization compared with men. Inflammation is increasingly implicated in both clinical studies and animal models as a potent mechanism driving AVF maturation, especially in vessel dilation and wall thickening, that allows venous remodeling to the fistula environment to support hemodialysis. Sex differences have long been recognized in arterial remodeling and diseases, with men having increased cardiovascular events compared with pre-menopausal women. Many of these arterial diseases are driven by inflammation that is similar to the inflammation during AVF maturation. Improved understanding of sex differences in inflammation during vascular remodeling may suggest sex-specific vascular therapies to improve AVF success.
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spelling pubmed-83354842021-08-05 Sex Differences in Inflammation During Venous Remodeling of Arteriovenous Fistulae Chan, Shin Mei Weininger, Gabe Langford, John Jane-Wit, Daniel Dardik, Alan Front Cardiovasc Med Cardiovascular Medicine Vascular disorders frequently have differing clinical presentations among women and men. Sex differences exist in vascular access for hemodialysis; women have reduced rates of arteriovenous fistula (AVF) maturation as well as fistula utilization compared with men. Inflammation is increasingly implicated in both clinical studies and animal models as a potent mechanism driving AVF maturation, especially in vessel dilation and wall thickening, that allows venous remodeling to the fistula environment to support hemodialysis. Sex differences have long been recognized in arterial remodeling and diseases, with men having increased cardiovascular events compared with pre-menopausal women. Many of these arterial diseases are driven by inflammation that is similar to the inflammation during AVF maturation. Improved understanding of sex differences in inflammation during vascular remodeling may suggest sex-specific vascular therapies to improve AVF success. Frontiers Media S.A. 2021-07-21 /pmc/articles/PMC8335484/ /pubmed/34368264 http://dx.doi.org/10.3389/fcvm.2021.715114 Text en Copyright © 2021 Chan, Weininger, Langford, Jane-Wit and Dardik. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Chan, Shin Mei
Weininger, Gabe
Langford, John
Jane-Wit, Daniel
Dardik, Alan
Sex Differences in Inflammation During Venous Remodeling of Arteriovenous Fistulae
title Sex Differences in Inflammation During Venous Remodeling of Arteriovenous Fistulae
title_full Sex Differences in Inflammation During Venous Remodeling of Arteriovenous Fistulae
title_fullStr Sex Differences in Inflammation During Venous Remodeling of Arteriovenous Fistulae
title_full_unstemmed Sex Differences in Inflammation During Venous Remodeling of Arteriovenous Fistulae
title_short Sex Differences in Inflammation During Venous Remodeling of Arteriovenous Fistulae
title_sort sex differences in inflammation during venous remodeling of arteriovenous fistulae
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8335484/
https://www.ncbi.nlm.nih.gov/pubmed/34368264
http://dx.doi.org/10.3389/fcvm.2021.715114
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