PDLIM1: Structure, function and implication in cancer

PDLIM1, a member of the PDZ-LIM family, is a cytoskeletal protein and functions as a platform to form distinct protein complexes, thus participating in multiple physiological processes such as cytoskeleton regulation and synapse formation. Emerging evidence demonstrates that PDLIM1 is dysregualted i...

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Detalles Bibliográficos
Autores principales: Zhou, Jian-Kang, Fan, Xin, Cheng, Jian, Liu, Wenrong, Peng, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shared Science Publishers OG 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8335553/
https://www.ncbi.nlm.nih.gov/pubmed/34396044
http://dx.doi.org/10.15698/cst2021.08.254
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author Zhou, Jian-Kang
Fan, Xin
Cheng, Jian
Liu, Wenrong
Peng, Yong
author_facet Zhou, Jian-Kang
Fan, Xin
Cheng, Jian
Liu, Wenrong
Peng, Yong
author_sort Zhou, Jian-Kang
collection PubMed
description PDLIM1, a member of the PDZ-LIM family, is a cytoskeletal protein and functions as a platform to form distinct protein complexes, thus participating in multiple physiological processes such as cytoskeleton regulation and synapse formation. Emerging evidence demonstrates that PDLIM1 is dysregualted in a variety of tumors and plays essential roles in tumor initiation and progression. In this review, we summarize the structure and function of PDLIM1, as well as its important roles in human cancers.
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spelling pubmed-83355532021-08-13 PDLIM1: Structure, function and implication in cancer Zhou, Jian-Kang Fan, Xin Cheng, Jian Liu, Wenrong Peng, Yong Cell Stress Review PDLIM1, a member of the PDZ-LIM family, is a cytoskeletal protein and functions as a platform to form distinct protein complexes, thus participating in multiple physiological processes such as cytoskeleton regulation and synapse formation. Emerging evidence demonstrates that PDLIM1 is dysregualted in a variety of tumors and plays essential roles in tumor initiation and progression. In this review, we summarize the structure and function of PDLIM1, as well as its important roles in human cancers. Shared Science Publishers OG 2021-07-26 /pmc/articles/PMC8335553/ /pubmed/34396044 http://dx.doi.org/10.15698/cst2021.08.254 Text en Copyright: © 2021 Zhou et al. https://creativecommons.org/licenses/by/4.0/This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged.
spellingShingle Review
Zhou, Jian-Kang
Fan, Xin
Cheng, Jian
Liu, Wenrong
Peng, Yong
PDLIM1: Structure, function and implication in cancer
title PDLIM1: Structure, function and implication in cancer
title_full PDLIM1: Structure, function and implication in cancer
title_fullStr PDLIM1: Structure, function and implication in cancer
title_full_unstemmed PDLIM1: Structure, function and implication in cancer
title_short PDLIM1: Structure, function and implication in cancer
title_sort pdlim1: structure, function and implication in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8335553/
https://www.ncbi.nlm.nih.gov/pubmed/34396044
http://dx.doi.org/10.15698/cst2021.08.254
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AT chengjian pdlim1structurefunctionandimplicationincancer
AT liuwenrong pdlim1structurefunctionandimplicationincancer
AT pengyong pdlim1structurefunctionandimplicationincancer

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