Cargando…
Advances in the mechanism and treatment of mitochondrial quality control involved in myocardial infarction
Mitochondria are important organelles in eukaryotic cells. Normal mitochondrial homeostasis is subject to a strict mitochondrial quality control system, including the strict regulation of mitochondrial production, fission/fusion and mitophagy. The strict and accurate modulation of the mitochondrial...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8335700/ https://www.ncbi.nlm.nih.gov/pubmed/34160885 http://dx.doi.org/10.1111/jcmm.16744 |
_version_ | 1783733173702623232 |
---|---|
author | Wang, Chunfang Liu, Leiling Wang, Yishu Xu, Danyan |
author_facet | Wang, Chunfang Liu, Leiling Wang, Yishu Xu, Danyan |
author_sort | Wang, Chunfang |
collection | PubMed |
description | Mitochondria are important organelles in eukaryotic cells. Normal mitochondrial homeostasis is subject to a strict mitochondrial quality control system, including the strict regulation of mitochondrial production, fission/fusion and mitophagy. The strict and accurate modulation of the mitochondrial quality control system, comprising the mitochondrial fission/fusion, mitophagy and other processes, can ameliorate the myocardial injury of myocardial ischaemia and ischaemia‐reperfusion after myocardial infarction, which plays an important role in myocardial protection after myocardial infarction. Further research into the mechanism will help identify new therapeutic targets and drugs for the treatment of myocardial infarction. This article aims to summarize the recent research regarding the mitochondrial quality control system and its molecular mechanism involved in myocardial infarction, as well as the potential therapeutic targets in the future. |
format | Online Article Text |
id | pubmed-8335700 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-83357002021-08-09 Advances in the mechanism and treatment of mitochondrial quality control involved in myocardial infarction Wang, Chunfang Liu, Leiling Wang, Yishu Xu, Danyan J Cell Mol Med Reviews Mitochondria are important organelles in eukaryotic cells. Normal mitochondrial homeostasis is subject to a strict mitochondrial quality control system, including the strict regulation of mitochondrial production, fission/fusion and mitophagy. The strict and accurate modulation of the mitochondrial quality control system, comprising the mitochondrial fission/fusion, mitophagy and other processes, can ameliorate the myocardial injury of myocardial ischaemia and ischaemia‐reperfusion after myocardial infarction, which plays an important role in myocardial protection after myocardial infarction. Further research into the mechanism will help identify new therapeutic targets and drugs for the treatment of myocardial infarction. This article aims to summarize the recent research regarding the mitochondrial quality control system and its molecular mechanism involved in myocardial infarction, as well as the potential therapeutic targets in the future. John Wiley and Sons Inc. 2021-06-23 2021-08 /pmc/articles/PMC8335700/ /pubmed/34160885 http://dx.doi.org/10.1111/jcmm.16744 Text en © 2021 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Reviews Wang, Chunfang Liu, Leiling Wang, Yishu Xu, Danyan Advances in the mechanism and treatment of mitochondrial quality control involved in myocardial infarction |
title | Advances in the mechanism and treatment of mitochondrial quality control involved in myocardial infarction |
title_full | Advances in the mechanism and treatment of mitochondrial quality control involved in myocardial infarction |
title_fullStr | Advances in the mechanism and treatment of mitochondrial quality control involved in myocardial infarction |
title_full_unstemmed | Advances in the mechanism and treatment of mitochondrial quality control involved in myocardial infarction |
title_short | Advances in the mechanism and treatment of mitochondrial quality control involved in myocardial infarction |
title_sort | advances in the mechanism and treatment of mitochondrial quality control involved in myocardial infarction |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8335700/ https://www.ncbi.nlm.nih.gov/pubmed/34160885 http://dx.doi.org/10.1111/jcmm.16744 |
work_keys_str_mv | AT wangchunfang advancesinthemechanismandtreatmentofmitochondrialqualitycontrolinvolvedinmyocardialinfarction AT liuleiling advancesinthemechanismandtreatmentofmitochondrialqualitycontrolinvolvedinmyocardialinfarction AT wangyishu advancesinthemechanismandtreatmentofmitochondrialqualitycontrolinvolvedinmyocardialinfarction AT xudanyan advancesinthemechanismandtreatmentofmitochondrialqualitycontrolinvolvedinmyocardialinfarction |