Multipotent Stromal Cells and Viral Interaction: Current Implications for Therapy

Multipotent stromal cells (MSCs) are widely utilized in therapy for their immunomodulatory properties, but their usage in infectious viral diseases is less explored. This review aimed to collate the current novel use of MSCs in virus-associated conditions, including MSC’s susceptibility to virus inf...

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Autores principales: Taechangam, Nopmanee, Kol, Amir, Arzi, Boaz, Borjesson, Dori L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8335712/
https://www.ncbi.nlm.nih.gov/pubmed/34347271
http://dx.doi.org/10.1007/s12015-021-10224-9
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author Taechangam, Nopmanee
Kol, Amir
Arzi, Boaz
Borjesson, Dori L.
author_facet Taechangam, Nopmanee
Kol, Amir
Arzi, Boaz
Borjesson, Dori L.
author_sort Taechangam, Nopmanee
collection PubMed
description Multipotent stromal cells (MSCs) are widely utilized in therapy for their immunomodulatory properties, but their usage in infectious viral diseases is less explored. This review aimed to collate the current novel use of MSCs in virus-associated conditions, including MSC’s susceptibility to virus infection, antiviral properties of MSCs and their effects on cell-based immune response and implementation of MSC therapy in animal models and human clinical trials of viral diseases. Recent discoveries shed lights on MSC’s capability in suppressing viral replication and augmenting clearance through enhancement of antiviral immunity. MSC therapy may maintain a crucial balance between aiding pathogen clearance and suppressing hyperactive immune response. GRAPHICAL ABSTRACT: [Image: see text]
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spelling pubmed-83357122021-08-04 Multipotent Stromal Cells and Viral Interaction: Current Implications for Therapy Taechangam, Nopmanee Kol, Amir Arzi, Boaz Borjesson, Dori L. Stem Cell Rev Rep Article Multipotent stromal cells (MSCs) are widely utilized in therapy for their immunomodulatory properties, but their usage in infectious viral diseases is less explored. This review aimed to collate the current novel use of MSCs in virus-associated conditions, including MSC’s susceptibility to virus infection, antiviral properties of MSCs and their effects on cell-based immune response and implementation of MSC therapy in animal models and human clinical trials of viral diseases. Recent discoveries shed lights on MSC’s capability in suppressing viral replication and augmenting clearance through enhancement of antiviral immunity. MSC therapy may maintain a crucial balance between aiding pathogen clearance and suppressing hyperactive immune response. GRAPHICAL ABSTRACT: [Image: see text] Springer US 2021-08-04 2022 /pmc/articles/PMC8335712/ /pubmed/34347271 http://dx.doi.org/10.1007/s12015-021-10224-9 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Taechangam, Nopmanee
Kol, Amir
Arzi, Boaz
Borjesson, Dori L.
Multipotent Stromal Cells and Viral Interaction: Current Implications for Therapy
title Multipotent Stromal Cells and Viral Interaction: Current Implications for Therapy
title_full Multipotent Stromal Cells and Viral Interaction: Current Implications for Therapy
title_fullStr Multipotent Stromal Cells and Viral Interaction: Current Implications for Therapy
title_full_unstemmed Multipotent Stromal Cells and Viral Interaction: Current Implications for Therapy
title_short Multipotent Stromal Cells and Viral Interaction: Current Implications for Therapy
title_sort multipotent stromal cells and viral interaction: current implications for therapy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8335712/
https://www.ncbi.nlm.nih.gov/pubmed/34347271
http://dx.doi.org/10.1007/s12015-021-10224-9
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