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Increased risk of postsurgical macular edema in high stage idiopathic epiretinal membranes

PURPOSE: To assess the rate of occurrence and the risk factors of postsurgical macular edema (PSME) in eyes with idiopathic epiretinal membrane (iERM) or full-thickness macular hole (FTMH). METHODS: Retrospective longitudinal analysis of all subjects scheduled for vitrectomy with or without combined...

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Autores principales: Iuliano, Lorenzo, Cisa di Gresy, Gloria, Fogliato, Giovanni, Corbelli, Eleonora, Bandello, Francesco, Codenotti, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8335864/
https://www.ncbi.nlm.nih.gov/pubmed/34348801
http://dx.doi.org/10.1186/s40662-021-00252-4
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author Iuliano, Lorenzo
Cisa di Gresy, Gloria
Fogliato, Giovanni
Corbelli, Eleonora
Bandello, Francesco
Codenotti, Marco
author_facet Iuliano, Lorenzo
Cisa di Gresy, Gloria
Fogliato, Giovanni
Corbelli, Eleonora
Bandello, Francesco
Codenotti, Marco
author_sort Iuliano, Lorenzo
collection PubMed
description PURPOSE: To assess the rate of occurrence and the risk factors of postsurgical macular edema (PSME) in eyes with idiopathic epiretinal membrane (iERM) or full-thickness macular hole (FTMH). METHODS: Retrospective longitudinal analysis of all subjects scheduled for vitrectomy with or without combined cataract surgery over a 6-month period. Electronic medical charts and imaging data were analyzed preoperatively and at 1, 3 and 6 months after surgery. RESULTS: From 101 patients diagnosed with iERM or FTMH, 71 patients were eligible for the study. Forty-nine eyes with iERM (69.0%) and 22 eyes with FTMH (31.0%) underwent vitrectomy either isolated (31.0%) or combined with cataract extraction (69.0%). The overall rate of PSME was 26.7%, without differences between the two groups (P = 0.9479). Combined cataract extraction did not affect the overall occurrence of PSME rate in both groups (P = 0.9255 in FTMH and P = 0.8658 in iERM). If grouped by stage, eyes with stage 4 iERM though disclosed an increased rate of PSME (57.1%) compared to lower (1 to 3) stages (14.3%, P = 0.0021), particularly when combined with cataract surgery (71.4% vs. 15.4% in stages ≤ 3, P = 0.0021). The PSME odds ratio for a stage 4 iERM is 8 (95% CI: 1.933–33.1; P = 0.0041) compared to stages 3 and below. CONCLUSIONS: PSME remains a clinically relevant and frequent event after surgery for iERM and FTMH. Patients with stage 4 iERM have an 8-fold higher likelihood of developing PSME in a 6-month postsurgical period compared to iERM in 1–3 stages, especially when combined with cataract extraction.
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spelling pubmed-83358642021-08-04 Increased risk of postsurgical macular edema in high stage idiopathic epiretinal membranes Iuliano, Lorenzo Cisa di Gresy, Gloria Fogliato, Giovanni Corbelli, Eleonora Bandello, Francesco Codenotti, Marco Eye Vis (Lond) Research PURPOSE: To assess the rate of occurrence and the risk factors of postsurgical macular edema (PSME) in eyes with idiopathic epiretinal membrane (iERM) or full-thickness macular hole (FTMH). METHODS: Retrospective longitudinal analysis of all subjects scheduled for vitrectomy with or without combined cataract surgery over a 6-month period. Electronic medical charts and imaging data were analyzed preoperatively and at 1, 3 and 6 months after surgery. RESULTS: From 101 patients diagnosed with iERM or FTMH, 71 patients were eligible for the study. Forty-nine eyes with iERM (69.0%) and 22 eyes with FTMH (31.0%) underwent vitrectomy either isolated (31.0%) or combined with cataract extraction (69.0%). The overall rate of PSME was 26.7%, without differences between the two groups (P = 0.9479). Combined cataract extraction did not affect the overall occurrence of PSME rate in both groups (P = 0.9255 in FTMH and P = 0.8658 in iERM). If grouped by stage, eyes with stage 4 iERM though disclosed an increased rate of PSME (57.1%) compared to lower (1 to 3) stages (14.3%, P = 0.0021), particularly when combined with cataract surgery (71.4% vs. 15.4% in stages ≤ 3, P = 0.0021). The PSME odds ratio for a stage 4 iERM is 8 (95% CI: 1.933–33.1; P = 0.0041) compared to stages 3 and below. CONCLUSIONS: PSME remains a clinically relevant and frequent event after surgery for iERM and FTMH. Patients with stage 4 iERM have an 8-fold higher likelihood of developing PSME in a 6-month postsurgical period compared to iERM in 1–3 stages, especially when combined with cataract extraction. BioMed Central 2021-08-04 /pmc/articles/PMC8335864/ /pubmed/34348801 http://dx.doi.org/10.1186/s40662-021-00252-4 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Iuliano, Lorenzo
Cisa di Gresy, Gloria
Fogliato, Giovanni
Corbelli, Eleonora
Bandello, Francesco
Codenotti, Marco
Increased risk of postsurgical macular edema in high stage idiopathic epiretinal membranes
title Increased risk of postsurgical macular edema in high stage idiopathic epiretinal membranes
title_full Increased risk of postsurgical macular edema in high stage idiopathic epiretinal membranes
title_fullStr Increased risk of postsurgical macular edema in high stage idiopathic epiretinal membranes
title_full_unstemmed Increased risk of postsurgical macular edema in high stage idiopathic epiretinal membranes
title_short Increased risk of postsurgical macular edema in high stage idiopathic epiretinal membranes
title_sort increased risk of postsurgical macular edema in high stage idiopathic epiretinal membranes
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8335864/
https://www.ncbi.nlm.nih.gov/pubmed/34348801
http://dx.doi.org/10.1186/s40662-021-00252-4
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