Cargando…

EHMT2 promotes the pathogenesis of hepatocellular carcinoma by epigenetically silencing APC expression

BACKGROUND: Hepatocellular carcinoma (HCC), the second leading cause of cancer death worldwide, alone accounts for over half (466,100) of new cancer cases and 422,100 deaths based on the average year incidence rates of 2009 to 2011 in China. Due to unclear and complex underlying mechanisms for HCC d...

Descripción completa

Detalles Bibliográficos
Autores principales:	Guo, Yuan, Zhao, Yan-Rong, Liu, Huan, Xin, Yang, Yu, Jian-Zhi, Zang, Yun-Jin, Xu, Qing-guo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8335875/ https://www.ncbi.nlm.nih.gov/pubmed/34344448 http://dx.doi.org/10.1186/s13578-021-00663-9

Ejemplares similares

Epigenetic Silencing of CHOP Expression by the Histone Methyltransferase EHMT1 Regulates Apoptosis in Colorectal Cancer Cells
por: Kim, Kwangho, et al.
Publicado: (2022)

Analogues of the natural product Sinefungin as potent inhibitors of EHMT1 and EHMT2
por: Devkota, Kanchan, et al.
Publicado: (2013)

Epigenetic regulation of APC in the molecular pathogenesis of gallbladder cancer
por: Tekcham, Dinesh Singh, et al.
Publicado: (2016)

EHMT2 directs DNA methylation for efficient gene silencing in mouse embryos
por: Auclair, Ghislain, et al.
Publicado: (2016)

Distinct functions of EHMT1 and EHMT2 in cancer chemotherapy and immunotherapy
por: Kang, Zhihua, et al.
Publicado: (2023)

Epigenetic Regulation of Learning and Memory by Drosophila EHMT/G9a
por: Kramer, Jamie M., et al.
Publicado: (2011)

APC promoter methylation and protein expression in hepatocellular carcinoma
por: Csepregi, Antal, et al.
Publicado: (2007)

EHMT2 epigenetically suppresses Wnt signaling and is a potential target in embryonal rhabdomyosarcoma
por: Pal, Ananya, et al.
Publicado: (2020)

EHMT2/G9a as an Epigenetic Target in Pediatric and Adult Brain Tumors
por: Souza, Barbara Kunzler, et al.
Publicado: (2021)

Epigenetic silencing of TMEM176A activates ERK signaling in human hepatocellular carcinoma
por: Li, Hongxia, et al.
Publicado: (2018)

Histone methyltransferases EHMT1 and EHMT2 (GLP/G9A) maintain PARP inhibitor resistance in high-grade serous ovarian carcinoma
por: Watson, Zachary L., et al.
Publicado: (2019)

MT1G is Silenced by DNA Methylation and Contributes to the Pathogenesis of Hepatocellular Carcinoma
por: Zeng, Ju-deng, et al.
Publicado: (2018)

Quantitative analysis of APC promoter methylation in hepatocellular carcinoma and its prognostic implications
por: XU, BAIYING, et al.
Publicado: (2014)

Epigenetic silencing of ZIC4 contributes to cancer progression in hepatocellular carcinoma
por: Chen, Wenbiao, et al.
Publicado: (2020)

TGF-β1 induces epigenetic silence of TIP30 to promote tumor metastasis in esophageal carcinoma
por: Bu, Fangfang, et al.
Publicado: (2014)

Identification by high-throughput imaging of the histone methyltransferase EHMT2 as an epigenetic regulator of VEGFA alternative splicing
por: Salton, Maayan, et al.
Publicado: (2014)

The Silencing of RECK Gene is Associated with Promoter Hypermethylation and Poor Survival in Hepatocellular Carcinoma
por: Zhang, Changsong, et al.
Publicado: (2012)

TNFα Effects on Adipocytes Are Influenced by the Presence of Lysine Methyltransferases, G9a (EHMT2) and GLP (EHMT1)
por: Able, Ashley A., et al.
Publicado: (2023)

Targeting EHMT2 reverses EGFR-TKI resistance in NSCLC by epigenetically regulating the PTEN/AKT signaling pathway
por: Wang, Lihui, et al.
Publicado: (2018)

De novo methylation of histone H3K23 by the methyltransferases EHMT1/GLP and EHMT2/G9a
por: Vinson, David A., et al.
Publicado: (2022)

Silencing HOXD10 by promoter region hypermethylation activates ERK signaling in hepatocellular carcinoma
por: Guo, Yulin, et al.
Publicado: (2017)

MDC1 methylation mediated by lysine methyltransferases EHMT1 and EHMT2 regulates active ATM accumulation flanking DNA damage sites
por: Watanabe, Sugiko, et al.
Publicado: (2018)

Histone Methyltransferases G9a/Ehmt2 and GLP/Ehmt1 Are Associated with Cell Viability and Poorer Prognosis in Neuroblastoma and Ewing Sarcoma
por: Souza, Barbara Kunzler, et al.
Publicado: (2023)

Metastasis-suppressing NID2, an epigenetically-silenced gene, in the pathogenesis of nasopharyngeal carcinoma and esophageal squamous cell carcinoma
por: Chai, Annie Wai Yeeng, et al.
Publicado: (2016)

Epigenetic silencing of JMJD5 promotes the proliferation of hepatocellular carcinoma cells by down-regulating the transcription of CDKN1A
por: Wu, Bing-Hao, et al.
Publicado: (2016)

Epigenetic silencing of miR-335 and its host gene MEST in hepatocellular carcinoma
por: DOHI, OSAMU, et al.
Publicado: (2012)

Epigenetic silencing of BCL6B inactivates p53 signaling and causes human hepatocellular carcinoma cell resist to 5-FU
por: Li, Xin, et al.
Publicado: (2015)

Inhibition of EHMT2/G9a epigenetically increases the transcription of Beclin-1 via an increase in ROS and activation of NF-κB
por: Park, Sang Eun, et al.
Publicado: (2016)

Gene Expression Characteristics of Liver Tissue Reveal the Underlying Pathogenesis of Hepatocellular Carcinoma
por: Guo, Congfang, et al.
Publicado: (2021)

Correction: Inhibition of EHMT2/G9a epigenetically increases the transcription of Beclin-1 via an increase in ROS and activation of NF-κB
por: Park, Sang Eun, et al.
Publicado: (2019)

Intragenic duplication of EHMT1 gene results in Kleefstra syndrome
por: Schwaibold, Eva Maria Christina, et al.
Publicado: (2014)

EHMT2 suppresses the variation of transcriptional switches in the mouse embryo
por: Zeng, Tie-Bo, et al.
Publicado: (2021)

Integrated genetic and epigenetic analysis reveals DNA repair alterations in multifocal hepatocellular carcinoma
por: Ling, Yi-Hong, et al.
Publicado: (2023)

Hypermethylation of APC2 Is a Predictive Epigenetic Biomarker for Chinese Colorectal Cancer
por: He, Yuan, et al.
Publicado: (2018)

RNAi silencing of c-Myc inhibits cell migration, invasion, and proliferation in HepG(2) human hepatocellular carcinoma cell line: c-Myc silencing in hepatocellular carcinoma cell
por: Zhao, Yan, et al.
Publicado: (2013)

Demethylation of EHMT1/GLP Protein Reprograms Its Transcriptional Activity and Promotes Prostate Cancer Progression
por: Besschetnova, Anna, et al.
Publicado: (2023)

Reduced expression of DACT2 promotes hepatocellular carcinoma progression: involvement of methylation-mediated gene silencing
por: Gao, Sheng, et al.
Publicado: (2013)

JMJD3 promotes esophageal squamous cell carcinoma pathogenesis through epigenetic regulation of MYC
por: Li, Shu-Man, et al.
Publicado: (2020)

LncRNA TRERNA1 facilitates hepatocellular carcinoma metastasis by dimethylating H3K9 in the CDH1 promoter region via the recruitment of the EHMT2/SNAI1 complex
por: Song, Wei, et al.
Publicado: (2019)

Epigenetic silencing of HIC1 promotes epithelial-mesenchymal transition and drives progression in esophageal squamous cell carcinoma
por: Li, Pei, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_egkaf6pkansu7f7b77t3sa1hik