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The prognostic and therapeutic implications of distinct patterns of argininosuccinate synthase 1 (ASS1) and arginase-2 (ARG2) expression by cancer cells and tumor stroma in non-small-cell lung cancer

BACKGROUND: Arginine (Arg) is essential for cancer cell growth and also for the activation of T cells. Thus, therapies aiming to reduce Arg utilization by cancer may prove detrimental for the immune response. METHODS: We examined the expression of two major enzymes involved in arginine depletion and...

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Detalles Bibliográficos
Autores principales:	Giatromanolaki, Alexandra, Harris, Adrian L., Koukourakis, Michael I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Short Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8336070/ https://www.ncbi.nlm.nih.gov/pubmed/34344457 http://dx.doi.org/10.1186/s40170-021-00264-7

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