Anti-inflammatory protein TNFα-stimulated gene-6 (TSG-6) reduces inflammatory response after brain injury in mice

BACKGROUND: Current research suggests that the glial scar surrounding penetrating brain injuries is instrumental in preserving the surrounding uninjured tissue by limiting the inflammatory response to the injury site. We recently showed that tumor necrosis factor (TNF)-stimulated gene-6 (TSG-6), a w...

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Autores principales: Mutoji, Kazadi Nadine, Sun, Mingxia, Nash, Amanda, Puri, Sudan, Hascall, Vincent, Coulson-Thomas, Vivien J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8336266/
https://www.ncbi.nlm.nih.gov/pubmed/34348643
http://dx.doi.org/10.1186/s12865-021-00443-7
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author Mutoji, Kazadi Nadine
Sun, Mingxia
Nash, Amanda
Puri, Sudan
Hascall, Vincent
Coulson-Thomas, Vivien J.
author_facet Mutoji, Kazadi Nadine
Sun, Mingxia
Nash, Amanda
Puri, Sudan
Hascall, Vincent
Coulson-Thomas, Vivien J.
author_sort Mutoji, Kazadi Nadine
collection PubMed
description BACKGROUND: Current research suggests that the glial scar surrounding penetrating brain injuries is instrumental in preserving the surrounding uninjured tissue by limiting the inflammatory response to the injury site. We recently showed that tumor necrosis factor (TNF)-stimulated gene-6 (TSG-6), a well-established anti-inflammatory molecule, is present within the glial scar. In the present study we investigated the role of TSG-6 within the glial scar using TSG-6 null and littermate control mice subjected to penetrating brain injuries. RESULTS: Our findings show that mice lacking TSG-6 present a more severe inflammatory response after injury, which was correlated with an enlarged area of astrogliosis beyond the injury site. CONCLUSION: Our data provides evidence that TSG-6 has an anti-inflammatory role within the glial scar.
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spelling pubmed-83362662021-08-04 Anti-inflammatory protein TNFα-stimulated gene-6 (TSG-6) reduces inflammatory response after brain injury in mice Mutoji, Kazadi Nadine Sun, Mingxia Nash, Amanda Puri, Sudan Hascall, Vincent Coulson-Thomas, Vivien J. BMC Immunol Research Article BACKGROUND: Current research suggests that the glial scar surrounding penetrating brain injuries is instrumental in preserving the surrounding uninjured tissue by limiting the inflammatory response to the injury site. We recently showed that tumor necrosis factor (TNF)-stimulated gene-6 (TSG-6), a well-established anti-inflammatory molecule, is present within the glial scar. In the present study we investigated the role of TSG-6 within the glial scar using TSG-6 null and littermate control mice subjected to penetrating brain injuries. RESULTS: Our findings show that mice lacking TSG-6 present a more severe inflammatory response after injury, which was correlated with an enlarged area of astrogliosis beyond the injury site. CONCLUSION: Our data provides evidence that TSG-6 has an anti-inflammatory role within the glial scar. BioMed Central 2021-08-04 /pmc/articles/PMC8336266/ /pubmed/34348643 http://dx.doi.org/10.1186/s12865-021-00443-7 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Mutoji, Kazadi Nadine
Sun, Mingxia
Nash, Amanda
Puri, Sudan
Hascall, Vincent
Coulson-Thomas, Vivien J.
Anti-inflammatory protein TNFα-stimulated gene-6 (TSG-6) reduces inflammatory response after brain injury in mice
title Anti-inflammatory protein TNFα-stimulated gene-6 (TSG-6) reduces inflammatory response after brain injury in mice
title_full Anti-inflammatory protein TNFα-stimulated gene-6 (TSG-6) reduces inflammatory response after brain injury in mice
title_fullStr Anti-inflammatory protein TNFα-stimulated gene-6 (TSG-6) reduces inflammatory response after brain injury in mice
title_full_unstemmed Anti-inflammatory protein TNFα-stimulated gene-6 (TSG-6) reduces inflammatory response after brain injury in mice
title_short Anti-inflammatory protein TNFα-stimulated gene-6 (TSG-6) reduces inflammatory response after brain injury in mice
title_sort anti-inflammatory protein tnfα-stimulated gene-6 (tsg-6) reduces inflammatory response after brain injury in mice
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8336266/
https://www.ncbi.nlm.nih.gov/pubmed/34348643
http://dx.doi.org/10.1186/s12865-021-00443-7
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