Total synthesis of (+)-spiroindimicin A and congeners unveils their antiparasitic activity

The spiroindimicins are a unique class of chlorinated indole alkaloids characterized by three heteroaromatic rings structured around a congested spirocyclic stereocenter. Here, we report the first total synthesis of (+)-spiroindimicin A, which bears a challenging C-3′/C-5′′-linked spiroindolenine. W...

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Detalles Bibliográficos
Autores principales: Zhang, Zhen, Ray, Sneha, Imlay, Leah, Callaghan, Lauren T., Niederstrasser, Hanspeter, Mallipeddi, Prema Latha, Posner, Bruce A., Wetzel, Dawn M., Phillips, Margaret A., Smith, Myles W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8336461/
https://www.ncbi.nlm.nih.gov/pubmed/34377425
http://dx.doi.org/10.1039/d1sc02838c

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8336461/
https://www.ncbi.nlm.nih.gov/pubmed/34377425
http://dx.doi.org/10.1039/d1sc02838c

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