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Total synthesis of (+)-spiroindimicin A and congeners unveils their antiparasitic activity
The spiroindimicins are a unique class of chlorinated indole alkaloids characterized by three heteroaromatic rings structured around a congested spirocyclic stereocenter. Here, we report the first total synthesis of (+)-spiroindimicin A, which bears a challenging C-3′/C-5′′-linked spiroindolenine. W...
Autores principales: | Zhang, Zhen, Ray, Sneha, Imlay, Leah, Callaghan, Lauren T., Niederstrasser, Hanspeter, Mallipeddi, Prema Latha, Posner, Bruce A., Wetzel, Dawn M., Phillips, Margaret A., Smith, Myles W. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8336461/ https://www.ncbi.nlm.nih.gov/pubmed/34377425 http://dx.doi.org/10.1039/d1sc02838c |
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