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Plant Natural Flavonoids Against Multidrug Resistant Pathogens

The increasing emergence and dissemination of multidrug resistant (MDR) bacterial pathogens accelerate the desires for new antibiotics. Natural products dominate the preferred chemical scaffolds for the discovery of antibacterial agents. Here, the potential of natural flavonoids from plants against...

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Autores principales: Song, Meirong, Liu, Ying, Li, Tingting, Liu, Xiaojia, Hao, Zhihui, Ding, Shuangyang, Panichayupakaranant, Pharkphoom, Zhu, Kui, Shen, Jianzhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8336499/
https://www.ncbi.nlm.nih.gov/pubmed/34041861
http://dx.doi.org/10.1002/advs.202100749
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author Song, Meirong
Liu, Ying
Li, Tingting
Liu, Xiaojia
Hao, Zhihui
Ding, Shuangyang
Panichayupakaranant, Pharkphoom
Zhu, Kui
Shen, Jianzhong
author_facet Song, Meirong
Liu, Ying
Li, Tingting
Liu, Xiaojia
Hao, Zhihui
Ding, Shuangyang
Panichayupakaranant, Pharkphoom
Zhu, Kui
Shen, Jianzhong
author_sort Song, Meirong
collection PubMed
description The increasing emergence and dissemination of multidrug resistant (MDR) bacterial pathogens accelerate the desires for new antibiotics. Natural products dominate the preferred chemical scaffolds for the discovery of antibacterial agents. Here, the potential of natural flavonoids from plants against MDR bacteria, is demonstrated. Structure–activity relationship analysis shows the prenylation modulates the activity of flavonoids and obtains two compounds, α‐mangostin (AMG) and isobavachalcone (IBC). AMG and IBC not only display rapid bactericidal activity against Gram‐positive bacteria, but also restore the susceptibility of colistin against Gram‐negative pathogens. Mechanistic studies generally show such compounds bind to the phospholipids of bacterial membrane, and result in the dissipation of proton motive force and metabolic perturbations, through distinctive modes of action. The efficacy of AMG and IBC in four models associated with infection or contamination, is demonstrated. These results suggest that natural products of plants may be a promising and underappreciated reservoir to circumvent the existing antibiotic resistance.
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spelling pubmed-83364992021-08-09 Plant Natural Flavonoids Against Multidrug Resistant Pathogens Song, Meirong Liu, Ying Li, Tingting Liu, Xiaojia Hao, Zhihui Ding, Shuangyang Panichayupakaranant, Pharkphoom Zhu, Kui Shen, Jianzhong Adv Sci (Weinh) Research Articles The increasing emergence and dissemination of multidrug resistant (MDR) bacterial pathogens accelerate the desires for new antibiotics. Natural products dominate the preferred chemical scaffolds for the discovery of antibacterial agents. Here, the potential of natural flavonoids from plants against MDR bacteria, is demonstrated. Structure–activity relationship analysis shows the prenylation modulates the activity of flavonoids and obtains two compounds, α‐mangostin (AMG) and isobavachalcone (IBC). AMG and IBC not only display rapid bactericidal activity against Gram‐positive bacteria, but also restore the susceptibility of colistin against Gram‐negative pathogens. Mechanistic studies generally show such compounds bind to the phospholipids of bacterial membrane, and result in the dissipation of proton motive force and metabolic perturbations, through distinctive modes of action. The efficacy of AMG and IBC in four models associated with infection or contamination, is demonstrated. These results suggest that natural products of plants may be a promising and underappreciated reservoir to circumvent the existing antibiotic resistance. John Wiley and Sons Inc. 2021-05-26 /pmc/articles/PMC8336499/ /pubmed/34041861 http://dx.doi.org/10.1002/advs.202100749 Text en © 2021 The Authors. Advanced Science published by Wiley‐VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Song, Meirong
Liu, Ying
Li, Tingting
Liu, Xiaojia
Hao, Zhihui
Ding, Shuangyang
Panichayupakaranant, Pharkphoom
Zhu, Kui
Shen, Jianzhong
Plant Natural Flavonoids Against Multidrug Resistant Pathogens
title Plant Natural Flavonoids Against Multidrug Resistant Pathogens
title_full Plant Natural Flavonoids Against Multidrug Resistant Pathogens
title_fullStr Plant Natural Flavonoids Against Multidrug Resistant Pathogens
title_full_unstemmed Plant Natural Flavonoids Against Multidrug Resistant Pathogens
title_short Plant Natural Flavonoids Against Multidrug Resistant Pathogens
title_sort plant natural flavonoids against multidrug resistant pathogens
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8336499/
https://www.ncbi.nlm.nih.gov/pubmed/34041861
http://dx.doi.org/10.1002/advs.202100749
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