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Plant Natural Flavonoids Against Multidrug Resistant Pathogens
The increasing emergence and dissemination of multidrug resistant (MDR) bacterial pathogens accelerate the desires for new antibiotics. Natural products dominate the preferred chemical scaffolds for the discovery of antibacterial agents. Here, the potential of natural flavonoids from plants against...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8336499/ https://www.ncbi.nlm.nih.gov/pubmed/34041861 http://dx.doi.org/10.1002/advs.202100749 |
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author | Song, Meirong Liu, Ying Li, Tingting Liu, Xiaojia Hao, Zhihui Ding, Shuangyang Panichayupakaranant, Pharkphoom Zhu, Kui Shen, Jianzhong |
author_facet | Song, Meirong Liu, Ying Li, Tingting Liu, Xiaojia Hao, Zhihui Ding, Shuangyang Panichayupakaranant, Pharkphoom Zhu, Kui Shen, Jianzhong |
author_sort | Song, Meirong |
collection | PubMed |
description | The increasing emergence and dissemination of multidrug resistant (MDR) bacterial pathogens accelerate the desires for new antibiotics. Natural products dominate the preferred chemical scaffolds for the discovery of antibacterial agents. Here, the potential of natural flavonoids from plants against MDR bacteria, is demonstrated. Structure–activity relationship analysis shows the prenylation modulates the activity of flavonoids and obtains two compounds, α‐mangostin (AMG) and isobavachalcone (IBC). AMG and IBC not only display rapid bactericidal activity against Gram‐positive bacteria, but also restore the susceptibility of colistin against Gram‐negative pathogens. Mechanistic studies generally show such compounds bind to the phospholipids of bacterial membrane, and result in the dissipation of proton motive force and metabolic perturbations, through distinctive modes of action. The efficacy of AMG and IBC in four models associated with infection or contamination, is demonstrated. These results suggest that natural products of plants may be a promising and underappreciated reservoir to circumvent the existing antibiotic resistance. |
format | Online Article Text |
id | pubmed-8336499 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-83364992021-08-09 Plant Natural Flavonoids Against Multidrug Resistant Pathogens Song, Meirong Liu, Ying Li, Tingting Liu, Xiaojia Hao, Zhihui Ding, Shuangyang Panichayupakaranant, Pharkphoom Zhu, Kui Shen, Jianzhong Adv Sci (Weinh) Research Articles The increasing emergence and dissemination of multidrug resistant (MDR) bacterial pathogens accelerate the desires for new antibiotics. Natural products dominate the preferred chemical scaffolds for the discovery of antibacterial agents. Here, the potential of natural flavonoids from plants against MDR bacteria, is demonstrated. Structure–activity relationship analysis shows the prenylation modulates the activity of flavonoids and obtains two compounds, α‐mangostin (AMG) and isobavachalcone (IBC). AMG and IBC not only display rapid bactericidal activity against Gram‐positive bacteria, but also restore the susceptibility of colistin against Gram‐negative pathogens. Mechanistic studies generally show such compounds bind to the phospholipids of bacterial membrane, and result in the dissipation of proton motive force and metabolic perturbations, through distinctive modes of action. The efficacy of AMG and IBC in four models associated with infection or contamination, is demonstrated. These results suggest that natural products of plants may be a promising and underappreciated reservoir to circumvent the existing antibiotic resistance. John Wiley and Sons Inc. 2021-05-26 /pmc/articles/PMC8336499/ /pubmed/34041861 http://dx.doi.org/10.1002/advs.202100749 Text en © 2021 The Authors. Advanced Science published by Wiley‐VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles Song, Meirong Liu, Ying Li, Tingting Liu, Xiaojia Hao, Zhihui Ding, Shuangyang Panichayupakaranant, Pharkphoom Zhu, Kui Shen, Jianzhong Plant Natural Flavonoids Against Multidrug Resistant Pathogens |
title | Plant Natural Flavonoids Against Multidrug Resistant Pathogens |
title_full | Plant Natural Flavonoids Against Multidrug Resistant Pathogens |
title_fullStr | Plant Natural Flavonoids Against Multidrug Resistant Pathogens |
title_full_unstemmed | Plant Natural Flavonoids Against Multidrug Resistant Pathogens |
title_short | Plant Natural Flavonoids Against Multidrug Resistant Pathogens |
title_sort | plant natural flavonoids against multidrug resistant pathogens |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8336499/ https://www.ncbi.nlm.nih.gov/pubmed/34041861 http://dx.doi.org/10.1002/advs.202100749 |
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