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Hyperbaric Oxygen Boosts PD‐1 Antibody Delivery and T Cell Infiltration for Augmented Immune Responses Against Solid Tumors

Aberrant mechanical properties and immunosuppression are the two key factors that limit the antitumor efficacy of T cell immune checkpoint blockade inhibitors, e.g., programmed cell death‐1 antibody (PD‐1 Ab), against solid tumors in the clinic. This study leverages hyperbaric oxygen (HBO) for the f...

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Autores principales: Liu, Xin, Ye, Ningbing, Liu, Sha, Guan, Jiankun, Deng, Qingyuan, Zhang, Zhijie, Xiao, Chen, Ding, Ze‐yang, Zhang, Bi‐xiang, Chen, Xiao‐ping, Li, Zifu, Yang, Xiangliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8336507/
https://www.ncbi.nlm.nih.gov/pubmed/34085419
http://dx.doi.org/10.1002/advs.202100233
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author Liu, Xin
Ye, Ningbing
Liu, Sha
Guan, Jiankun
Deng, Qingyuan
Zhang, Zhijie
Xiao, Chen
Ding, Ze‐yang
Zhang, Bi‐xiang
Chen, Xiao‐ping
Li, Zifu
Yang, Xiangliang
author_facet Liu, Xin
Ye, Ningbing
Liu, Sha
Guan, Jiankun
Deng, Qingyuan
Zhang, Zhijie
Xiao, Chen
Ding, Ze‐yang
Zhang, Bi‐xiang
Chen, Xiao‐ping
Li, Zifu
Yang, Xiangliang
author_sort Liu, Xin
collection PubMed
description Aberrant mechanical properties and immunosuppression are the two key factors that limit the antitumor efficacy of T cell immune checkpoint blockade inhibitors, e.g., programmed cell death‐1 antibody (PD‐1 Ab), against solid tumors in the clinic. This study leverages hyperbaric oxygen (HBO) for the first time to address these two issues and reports the PD‐1‐Ab‐mediated immune responses against various stroma‐rich solid malignancies. The results demonstrate that HBO promoted PD‐1 Ab delivery and T cells infiltration into tumor parenchyma by depleting the extracellular matrix's main components, such as collagen and fibronectin. Furthermore, HBO disrupts hypoxia‐mediated immunosuppression and helps PD‐1 Ab trigger robust cytotoxic T lymphocytes and long‐lasting immunological memory to inhibit tumor relapses. Such enhanced immune responses are effective in solid tumors from rodents and the cancer cells from hepatocellular carcinoma patients. The results illustrate that HBO bolsters antitumor efficacy of PD‐1 Ab, and the HBO–PD‐1 Ab combination is a promising stroma‐rich solid tumors’ treatment in the clinic.
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spelling pubmed-83365072021-08-09 Hyperbaric Oxygen Boosts PD‐1 Antibody Delivery and T Cell Infiltration for Augmented Immune Responses Against Solid Tumors Liu, Xin Ye, Ningbing Liu, Sha Guan, Jiankun Deng, Qingyuan Zhang, Zhijie Xiao, Chen Ding, Ze‐yang Zhang, Bi‐xiang Chen, Xiao‐ping Li, Zifu Yang, Xiangliang Adv Sci (Weinh) Research Articles Aberrant mechanical properties and immunosuppression are the two key factors that limit the antitumor efficacy of T cell immune checkpoint blockade inhibitors, e.g., programmed cell death‐1 antibody (PD‐1 Ab), against solid tumors in the clinic. This study leverages hyperbaric oxygen (HBO) for the first time to address these two issues and reports the PD‐1‐Ab‐mediated immune responses against various stroma‐rich solid malignancies. The results demonstrate that HBO promoted PD‐1 Ab delivery and T cells infiltration into tumor parenchyma by depleting the extracellular matrix's main components, such as collagen and fibronectin. Furthermore, HBO disrupts hypoxia‐mediated immunosuppression and helps PD‐1 Ab trigger robust cytotoxic T lymphocytes and long‐lasting immunological memory to inhibit tumor relapses. Such enhanced immune responses are effective in solid tumors from rodents and the cancer cells from hepatocellular carcinoma patients. The results illustrate that HBO bolsters antitumor efficacy of PD‐1 Ab, and the HBO–PD‐1 Ab combination is a promising stroma‐rich solid tumors’ treatment in the clinic. John Wiley and Sons Inc. 2021-06-03 /pmc/articles/PMC8336507/ /pubmed/34085419 http://dx.doi.org/10.1002/advs.202100233 Text en © 2021 The Authors. Advanced Science published by Wiley‐VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Liu, Xin
Ye, Ningbing
Liu, Sha
Guan, Jiankun
Deng, Qingyuan
Zhang, Zhijie
Xiao, Chen
Ding, Ze‐yang
Zhang, Bi‐xiang
Chen, Xiao‐ping
Li, Zifu
Yang, Xiangliang
Hyperbaric Oxygen Boosts PD‐1 Antibody Delivery and T Cell Infiltration for Augmented Immune Responses Against Solid Tumors
title Hyperbaric Oxygen Boosts PD‐1 Antibody Delivery and T Cell Infiltration for Augmented Immune Responses Against Solid Tumors
title_full Hyperbaric Oxygen Boosts PD‐1 Antibody Delivery and T Cell Infiltration for Augmented Immune Responses Against Solid Tumors
title_fullStr Hyperbaric Oxygen Boosts PD‐1 Antibody Delivery and T Cell Infiltration for Augmented Immune Responses Against Solid Tumors
title_full_unstemmed Hyperbaric Oxygen Boosts PD‐1 Antibody Delivery and T Cell Infiltration for Augmented Immune Responses Against Solid Tumors
title_short Hyperbaric Oxygen Boosts PD‐1 Antibody Delivery and T Cell Infiltration for Augmented Immune Responses Against Solid Tumors
title_sort hyperbaric oxygen boosts pd‐1 antibody delivery and t cell infiltration for augmented immune responses against solid tumors
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8336507/
https://www.ncbi.nlm.nih.gov/pubmed/34085419
http://dx.doi.org/10.1002/advs.202100233
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